Parkinsonism Related Disorders [2011] Jun 27 [Epub ahead of print] (Valadas A, Coelho M, Mestre T, Guedes LC, Finisterra M, Noronha A, Rosa MM, Sampaio C, Ferreira JJ.)
Limited data is available regarding the motivations and concerns of people with Parkinson's Disease when participating in clinical trials. Knowledge of these factors may improve the recruitment and quality of future trials.
When asked for their reasons the main reasons for participating in clinical trials were : to help the advance of science (63%), to gain access to a better treatment (56%), and to benefit others (51%). The major concerns were : the risk of adverse events (49%) and the negative effects of treatment (35%). 90% reported they had understood the informed consent. Only 64% understood what the placebo effect meant. 66% of patients would participate in another clinical trial, but only 41% of patients would participate in a placebo-controlled trial.
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