ß-ASARONE INCREASES L-DOPA IN PARKINSON'S DISEASE

Clinical and Experimental Pharmacology and Physiology [2014] Jun 7 [Epub ahead of print]
(L.Huang, M.Deng, S.Zhang, Y.Fang, L.Li)

Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/24910244

In order to increase the effect of L-dopa it is usually administered in combination with a dopa
decarboxylase inhibitor. In Sinemet, L-dopa is combined with carbidopa. In Madopar,
L-dopa is combined with benserazide. The co-administration of ß-asarone and Levodopa is
being developed as a means of improving the effect of L-dopa even further.
ß-asarone is found in the flowering plant acorus and also in asarum, which is known as wild
ginger. For more information go to Asarone : http://en.wikipedia.org/wiki/Asarone
In animal studies the use of L-dopa in combination with ß-asarone was
compared to the use of existing methods of treating Parkinson's Disease.
Dopamine levels were found to increase in the brain (in the striatum) and in
blood plasma in response to ß-asarone. The co-administration of ß-asarone
and L-dopa could also increase the levels in blood plasma of tryosine
hydroxylase, which is the enzyme responsible for the formation of L-dopa.
Altogether, ß-asarone was found to have an effect on converting L-dopa
into dopamine by modulating the activity of dopamine metabolism.
The mechanism of co-administration of ß-asarone and L-dopa is different from that of
Sinemet and Madopar in the treatment of Parkinson's Disease. So the co-administration of
ß-asarone and L-dopa may be more beneficial to Parkinson's Disease treatment than the
existing methods and so could eventually replace them.