WEARING OFF IN PARKINSON'S DISEASE

28th September 2014 - New research

Parkinsonism Related Disorders [2014] 20 (2) : 204-211 (F.Stocchi, A.Antonini, P.Barone,
M.Tinazzi, M.Zappia, M.Onofrj, S.Ruggieri, L.Morgante, U.Bonuccelli, L.Lopiano, P.
Pramstaller, A.Albanese, M.Attar, V.Posocco, D.Colombo, G.Abbruzzese)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/24275586
Wearing off of the effect of drugs for Parkinson's Disease has been found to occur far earlier
and in more people with Parkinson's Disease than previously assumed. Wearing off is very
individual and there is no standard time frame for when this may occur or which symptoms
are experienced. For more information go to :
http://www.epda.eu.com/en/parkinsons/in-depth/medication/wearing-off/wearing-off-symptoms/
Neurologists found that there was wearing off in 57% of
people with Parkinson's Disease. However, when this was
assessed by the patients themselves, there was found to be
wearing off in 67% of people with Parkinson's Disease. Even
in people who had Parkinson's Disease for less than 2.5 years
there was wearing off in 21% of people when assessed by
neurologists and in 41% when patients assessed themselves.
The most frequent wearing off symptoms were slowness of
movements (55%) and reduced dexterity (48%). Those
factors most associated with wearing off were : younger age,

female gender, severer symptoms, and duration of treatment.
Wearing Off is already common in the early stages of Parkinson's Disease
 and is underestimated by routine neurological clinical evaluation. 
The effect of Parkinson's Disease drugs is therefore often relatively short lived.



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