Israelis Discover Clear Link Between Diabetes And Parkinson’s Disease

Neurons

Health News 

Maya Yarowsky, NoCamels | Oct, 20 2014

Basing their research on previous studies that showed amylin is also found in the brain and is related to Alzheimer’s disease when it clumps together, Miller discovered that this same hormone could cause Parkinson’s in patients with diabetes. “Our findings led us to the hypothesis that if amylin is located in the brain it can also interact with other proteins and peptides in the brain,” Miller tells ISRAEL21c.

 

Dr. Yifat Miller

From here, Miller and her team observed how NAC, which is part of a protein called alpha-synuclein, led to the death of neurons at an atomic level. By mapping the atomic structure of NAC and showing how it aggregates itself throughout the brain, Miller revealed for the first time the clumping mechanism in the brain that leads to Parkinson’s disease. All that was left was for her and her team to show that the presence of amylin in the brain and pancreas, and its clumping habits, could be the explanation for why Type II diabetics are at higher risk of contracting neurodegenerative diseases.

The first step on the road to an effective Parkinson’s treatment?

Using sophisticated computer simulations to examine how NAC interacts with amylin in the brain, Miller was able to support her conclusion that the synergy between these elements is what explains the higher neurodegenerative risk for diabetes patients. “We propose that NAC and amylin aggregate together and kill neuron cells, and these aggregates lead to Parkinson’s disease,” says Miller, clarifying that its NAC and amylin taken together that increase the risk of developing the disease.

Miller’s findings on the NAC-amylin interaction were confirmed in experiments, and she hopes that they will be used by other researchers to produce more effective Parkinson’s medication. “Publishing our results will allow other scientists to use this information to learn more about Parkinson’s, its mechanisms and possible drugs to reduce aggregation. Now one could develop a drug to prevent this interaction so the risk of diabetes will not lead to the risk of Parkinson’s,” says Miller.

Though the research conducted by Miller and her laboratory has yet to be published, it is some of the first to effectively examine the mechanism that causes Parkinson’s disease, a novel endeavor that has won her grants from the European Union Seventh Framework Programme, among other scientific bodies. While it is still unclear what about diabetes, besides the presence of the amylin hormone, triggers a higher risk for Parkinson’s disease, Miller and her team are well on their way to finding out.

Photos: Image Editor/ Dani Machlis, BGU/ Open Knowledge

http://nocamels.com/2014/10/israelis-discover-clear-link-between-diabetes-and-parkinsons-disease/