AMPHETAMINES INCREASE THE RISK OF PARKINSON'S DISEASE

12th December 2014 - New research

Previous neurotoxicity findings raised concerns that Amphetamines and Methamphetamines might damage dopaminergic neurons, resulting in dopamine-related medical disorders such as Parkinson's Disease. However, despite widespread use of methamphetamines and other amphetamine type stimulants little was known about the long-term medical consequences of

their abuse and dependence.

A retrospective design was used to examine medical records from 1996 until 2011. Patients were divided between (1) Amphetamine and Methamphetamine users, (2) Cocaine users, (3) those people that have not been exposed to drugs or alcohol. They were assessed to see if they were at an increased risk of developing either (1) Parkinson's Disease, or (2) Parkinson's Disease / Parkinsonism / Essential Tremor when compared to people that did not take drugs.

In Methamphetamine and Amphetamine users there was a nearly three fold increased risk of Parkinson's Disease, thereby indicating them as a cause of Parkinson's Disease. However, Cocaine users did not show any elevated risk of Parkinson's Disease.

The increased likelihood of developing Parkinson's Disease probably occurs because of the long term effect of amphetamines on the dopamine receptors, which they affect.

Reference : Drug and Alcohol Dependence [2014] Nov 16 [Epub ahead of print] (K.Curtin,

A.E.Fleckenstein, R.J.Robison, M.J.Crookston, K.R.Smith, G.R.Hanson)

http://www.viartis.net/parkinsons.disease/news/141212.pdf

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