Injectable Brain Implants Talk to Single Neurons

By Simon Makin March 1, 2016

New implants made of fine, flexible mesh last longer and cause less damage than current ones do

Brain implants have been around for decades—stimulating motor areas to alleviate Parkinson's disease symptoms, for example—but until now they have all suffered from the same limitation: because brains move slightly during 

physical activity and as we breathe and our heart beats, rigid implants rub and damage tissue. This means that eventually, because of both movement and scar-tissue formation, they lose contact with the cells they were monitoring.

Now a group of researchers, led by chemist Charles Lieber of Harvard University, has overcome these problems using a fine, flexible mesh. In 2012 the team showed that cells could be grown around such a mesh, but that left the problem of how to get one inside a living brain. The solution the scientists devised was to draw the mesh—measuring a few millimeters wide—into a syringe, so it would roll up like a scroll inside the 100-micron-wide needle, and inject it through a hole in the skull.

In a study published in Nature Nanotechnology last year, the team injected meshes studded with 16 electrodes into two brain regions in mice. The mesh is composed of extremely thin, nanoscale polymer threads, sparsely distributed so that 95 percent of it is empty space. It has a level of flexibility similar to brain tissue. “You're starting to make this nonliving system look like the biological system you're trying to probe,” Lieber explains. “That's been the goal of my group's work, to blur the distinction between electronics as we know it and the computer inside our heads.”

Once inside, the mesh unfurls—either enough to meet the sides of brain cavities called ventricles or very slightly if injected into solid tissue—to form a three-dimensional structure. The researchers showed that the implants integrated with tissue to form stable connections, with no inflammation five weeks later. “It's the dawn of biointegration,” says Ivan Minev of the Center for Neuroprosthetics at the Swiss Federal Institute of Technology in Lausanne, who was not involved in the work.

The researchers claim the mesh can be positioned with an accuracy approaching the scale of individual neurons. Activity can then be recorded to study the workings of brain circuitry, or neurons can be stimulated for therapeutic applications such as the deep-brain stimulation used to treat Parkinson's disease. One application Lieber envisions is injecting implants into the brains of stroke victims alongside neural stem cells to study how the stem cells grow and alter neural circuitry during recovery. “This opens up unprecedented opportunities, both for fundamental brain science and for any therapeutic applications where you need stability beyond a very short time,” Lieber says. He believes the device could “completely change the picture of what's possible with electrical brain interfaces.

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