The Michael J.Fox Foundation is assessing the clinical use and development of the cancer
drug nilotinib for treating Parkinson's Disease by carrying out a full scale clinical trial.
Nilotinib is a drug approved for chronic myelogenous leukemia, a cancer of the white blood
cells, under the brand name Tasigna.
For more information go to Michael J. Fox Foundation :
https://www.michaeljfox.org/foundation/news-detail.php?nilotinib-update-where-we-stand-w it-cancer-drug-for-parkinson
Previous studies have concerned the possible use of
nilotinib and Parkinson's Disease. Their findings are
summarised here. Nilotinib is a cAbl tyrosine kinase
inhibitor that is normally used for the treatment of
cancer. It is claimed to facilitate the degradation of
alpha-synuclein. Efficacy has only been assessed
concerning motor function in animals that did not have
Parkinson's Disease. Doses of 150mg or 300mg for 6
months were claimed to be safe and well tolerated
despite side effects including one serious side effect.
For more details of the previous studies concerning nilotinib and Parkinson's Disease go to :
http://www.ncbi.nlm.nih.gov/pubmed/?term=Nilotinib+%22parkinson%27s+disease%22
Although alpha-synuclein is often claimed to cause and indicate Parkinson's Disease,
alph-synuclein accumulates in a variety of neurological conditions and in people who do not
have neurological disorders. Therefore, an accumulation of alpha-synuclein does not indicate
that somebody has Parkinson's Disease. In Parkinson's Disease, the faulty formation of
L-dopa causes the formation of the superoxide anion, which causes the aggregation of
alpha-synuclein. So instead of alpha-synuclein accumulation being the cause of Parkinson's
Disease, Parkinson's Disease causes an accumulation of alpha-synuclein.
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http://www.viartis.net/parkinsons.disease/news/160731.pdf
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