Scientists identify new lead in search for Parkinson's cure

Date: October 5, 2016

Source: Iowa State University

Summary:

A protein that may safeguard neurons from the ravages of Parkinson’s disease has been identified by a team of scientists. Parkinson's disease is a progressive disorder that takes years to develop. A better understanding of Prokineticin-2 could turn up a means of slowing development of the disease or lead to new therapies, say the investigators.

This diagram demonstrates how the neuropeptide Prokineticin-2 (PK2) is rapidly induced during early stages of neurotoxic stress and secreted into extracellular spaces. ISU biomedical scientists have published new research indicating PK2 may act as a protective mechanism that helps neurons cope with Parkinson’s disease.  Credit: Anumantha Kanthasamy

Recently published research from Iowa State University may hint at a new treatment for Parkinson's disease.

In a paper published in the academic journal Nature Communications, ISU scientists identified a protein called Prokineticin-2 (PK2) that may protect brain cells and is expressed with greater frequency in the early stages of Parkinson's disease.

"The neurons use PK2 to cope with stress. It's an in-built protective mechanism," said Anumantha Kanthasamy, a Clarence Hartley Covault Distinguished Professor in veterinary medicine, the Eugene and Linda Lloyd Endowed Chair of Neurotoxicology, and chair of biomedical sciences at Iowa State. Kanthasamy, one of the paper's lead authors, has been working to understand the complex mechanisms of Parkinson's and searching for a cure for the past two decades.

Prokineticin-2 stimulates the neurons to produce more mitochondria, the part of the cell that produces energy. The resulting improved energy production helps neurons withstand the ravages of the disease, which is a neurological disorder that results in insufficient levels of dopamine in the brain.

Parkinson's disease is a progressive disorder that takes years to develop. A better understanding of Prokineticin-2 could turn up a means of slowing development of the disease or lead to new therapies, Kanthasamy said. For instance, there may be ways to stimulate more production of the protein or protein analogs to bind with its receptors on neurons, he said.

The research team took a multidisciplinary and integrated approach to studying Parkinson's disease. The study was funded by a grant from the National Institutes of Health to Kanthasamy and Arthi Kanthasamy, a professor of biomedical sciences and Anumantha's spouse. Six graduate students in Kanthasamy's lab also contributed to the study, including co-first authors Richard Gordon and Matthew Neal, as well as researchers at other institutions.

The scientists studied cultured brain cells, a rodent model and post-mortem human brains to track changes brought on by Parkinson's disease, and they confirmed a high expression of Prokineticin-2 in each facet of the study.

It was this team effort that resulted in a comprehensive finding, Arthi Kanthasamy noted.

The discovery prompted the research team to investigate more thoroughly.

"Of the thousands and thousands of factors we tracked in our experiments, why was this protein expressed so highly?" Arthi Kanthasamy said.

Finding the answer to that question poses a challenge that will take time to overcome, but the potential appears to be significant, she said.

Story Source:

Materials provided by Iowa State University. Note: Content may be edited for style and length.

/story_source

Journal Reference:

Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy, Arthi Kanthasamy. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 2016; 7: 12932 DOI: 10.1038/ncomms12932

https://www.sciencedaily.com/releases/2016/10/161005084313.htm