January 23, 2018
Although it is sometimes claimed that an accumulation of alpha-synuclein causes
Parkinson’s Disease, Parkinson’s Disease instead can cause alpha-synuclein to accumulate.
It has been suggested that alpha-synuclein could therefore be a valuable biomarker for
Parkinson’s Disease. So the levels of alpha-synuclein in the plasma was assessed in various
types of Parkinson’s Disease. Alpha-synuclein is commonly found in the brain. For more
information go to : https://en.wikipedia.org/wiki/Alpha-synuclein
Methods: People with Parkinson’s Disease were compared
to healthy volunteers who were matched by age and gender.
They were assessed with Parkinson’s Disease symptom
scales. However, the levels of alpha-synuclein did not differ
significantly between people with Parkinson’s Disease and
people who did not have Parkinson’s Disease. There was no
difference between different subtypes either. Yet there was
an inverse correlation between alpha-synuclein and the
Postural Instability and Gait Disorder (PIGD) subtype.
Conclusions: Plasma alpha-synuclein levels are not valuable biomarkers of Parkinson’s
Disease. It does not differ in the subtypes of Parkinson’s Disease either. However, there is an
inverse relation between plasma alpha-synuclein levels level and the severity of Parkinson’s
Disease in the Postural Instability and Gait Disorder (PIGD) subtype.
Reference : Neurologia i Neurochirurgia Polska [2017] Nov 21 [Epub ahead of print] (M.
Malec-Litwinowicz, A.Plewka, D.Plewka, E.Bogunia, M.Morek, A.Szczudlik, M. Szubiga,
M.Rudzinska-Bar)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/29342421
http://www.viartis.net/parkinsons.disease/news/180123.pdf
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