Berries vs. Pesticides in Parkinson’s Disease

April 4, 2018

In the original description of Parkinson’s disease, by none other than Dr. James Parkinson himself, these specific characteristics are mentioned: constipation, torpid or lethargic bowels, which may precede the diagnosis by many years.

In fact, bowel movement frequency may be predictive. Men with less than one bowel movement a day were four times more like likely to develop Parkinson’s an average of 12 years later. This could be simply a really early symptom of the disease tied to decreased water intake. Many Parkinson’s patients report never really feeling very thirsty, and perhaps that led to the constipation.

Alternately, one may speculate that constipation also increases the risk of Parkinson’s disease as constipation results in a longer stay of the feces in the bowel and thus more absorption of “neurotoxicants,” neurotoxins from the diet.

Two studies suggest an association between constipation and Parkinson’s, but, at the same time, 38 studies link the disease to pesticide exposure and by now more than 100 studies link pesticides to an increased risk of up to 80 percent.

Many of these studies are on occupational exposure, like that experienced by farmworkers, who may reduce their risk of Parkinson’s by wearing gloves and washing their clothes, but Parkinson’s has also been linked to ambient exposure. In the United States where approximately a billion pounds of pesticides are applied annually, just living or working in high-spray areas may increase Parkinson’s risk. It’s the same with using pesticides in the home: a study out of UCLA suggests applying certain pesticides to our lawns and crops may not be such a good idea.

Pesticides may cause DNA mutations that increase susceptibility for Parkinson’s or play a more direct role. Many neurodegenerative diseases appear to be caused by the buildup of misfolded proteins. In Parkinson’s disease, it’s a protein called alpha synuclein.

The buildup of synuclein may play a role in killing off specialized nerve cells in the brain, 70 percent of which may be gone by the time the first symptoms arise. Pesticides are so good at killing these neurons that researchers use them to try to recreate Parkinson’s disease in animals. Is there any way to stop the process? As of this writing, there aren’t yet any drugs that can prevent this protein aggregation.

What about flavonoid phytonutrients, natural compounds found in certain fruits and vegetables? Flavonoids can cross the blood-brain barrier and may have neuroprotective effects, so researchers tested 48 different plant compounds to see if any could stop the clumping of synuclein proteins into the little fibers that clog up the cell. And, indeed, they found a variety of flavonoids that can not only inhibit the spider web-like formation of synuclein fibers, but some could even break them up. It turns out flavonoids may actually bind to synuclein proteins and stabilize them.

In my video Berries vs. Pesticides in Parkinson’s Disease, you can see healthy nerve cells and the neurites, the arms they use to communicate to one another. After exposure to a pesticide, however, you can see how the cell is damaged and the arms are retracted. But, if you first incubate the nerve cells with a blueberry extract, the nerve cell appears better able to withstand the pesticide effects. So, this implies that flavonoids in our diet may be combatting Parkinson’s disease as we speak, and healthy diets may be effective in preventing and even curing the disorder. However, these were all petri dish experiments in a laboratory. Is there any evidence that people eating berries are protected from Parkinson’s?

A study published quite a long time ago suggested the consumption of blueberries and strawberries was protective, but it was a tiny study and its results were not statistically significant. Nevertheless, that was the best we had…until now. In a more recent study, those eating a variety of phytonutrients were less likely to develop Parkinson’s disease. Specifically, higher intake of berries was associated with significantly lower risk.

The accompanying editorial, “An Apple a Day to Prevent Parkinson Disease,” concludedthat more research is necessary, but, until then, “an apple a day might be a good idea.” Of course, that’s coming from a man. Apples appeared protective against Parkinson’s for men, but not women. However, everyone appeared to benefit from the berries.

We may not want to have our berries with cream, though, as milk may be contaminatedwith the same kind of neurotoxic pesticide residues found in the brains of Parkinson’s disease victims.

https://youtu.be/ZllweNj2DYU

I’ve produced other videos on Parkinson’s disease, including:

• Preventing Parkinson’s Disease with Diet
• Treating Parkinson’s Disease with Diet
• Is Something in Tobacco Protective Against Parkinson’s Disease?

The same reason Parkinson’s may be related to constipation may also explain the breast cancer connection. For more on this, see my video Breast Cancer and Constipation.

But what about all the sugar in fruit? See my videos If Fructose Is Bad, What About Fruit? and How Much Fruit Is Too Much?.

In health,

Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations—2013: Uprooting the Leading Causes of Death and More Than an Apple a Day, 2014: From Table to Able: Combating Disabling Diseases with Food, 2015: Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet, and my latest, 2016: How Not to Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers.

https://www.care2.com/greenliving/berries-vs-pesticides-in-parkinsons-disease.html