Annals of Neurology [2011] Nov 14 [Epub ahead of print] (S.M.Goldman, P.J.Quinlan, G.W.Ross, C.Marras, C.Meng, G.S.Bhudhikanok, K.Comyns, M.Korell, A.R.Chade, M.Kasten, B.Priestley, K.L.Chou, H.H.Fernandez, F.Cambi, J.W.Langston, C.M.Tanner)
Exposure to the solvent Trichloroethylene has been found to multiply the risk of Parkinson's Disease by six times. Results were similar for estimates of exposure duration and cumulative lifetime exposure. Trichloroethylene is a solvent that is used extensively in industry and the military and is a common environmental contaminant. It has been used to extract vegetable oils, in coffee decaffeination, and in the preparation of flavouring extracts from hops and spices. Much of its use has been banned because of toxicity. Trichloroethylene is the most common organic contaminant in groundwater, and so can cause toxicity via the water supply. Around 30% of U.S. water supplies are contaminated by Trichloroethylene. For more information go to Trichloroethylene. A previous study showed that workers with workstations adjacent to the source of Trichloroethylene and who were subjected to chronic inhalation and dermal exposure from handling Trichloroethylene soaked metal parts all had Parkinson's disease. Lesser chronic respiratory exposure to Trichloroethylene led to many features of Parkinsonism.
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