Melanoma incidence is higher in people affected by Parkinson's Disease but the genetic link
shared by both diseases was unknown. The Parkin gene (PARK2) is often mutated in
Parkinson's Disease and is consequently sometimes a genetic cause of Parkinson's Disease.
However, PARK2 is also a tumor suppressor gene both of melanoma predisposition and
progression. Melanoma is a form of skin cancer more common in Parkinson's Disease. For
more information go to : http://www.skincancer.org/skin-cancer-information/melanoma
An in-depth analysis of the PARK2 (Parkin) gene showed that
mutations were present far more often in Parkinson's Disease,
making Parkinson's Disease nearly four times more likely. The
formation of the Parkin gene occurs in melanocytes but not in
most cells in which there is melanoma. The formation of the
Parkin gene in melanoma cell lines resulted in a drastic reduction
of cell proliferation. Inhibition of the Parkin gene in melanocytes
stimulated their proliferation.
The results show an important role for the Parkin gene (PARK2), not only in Parkinson's
Disease, but also as a tumor suppressor both in melanoma predisposition and progression,
which could explain the association between Parkinson's Disease and melanoma.
Reference : Journal of the National Cancer Institute [2015] 108 (3) pii : djv340 (H.H.Hu,
C.Kannengiesser, S.Lesage, J.André, S.Mourah, L.Michel, V.Descamps, N.Basset-Seguin,
M.Bagot, A.Bensussan, C.Lebbé, L.Deschamps, P.Saiag, M.T.Leccia, B.Bressac-de-
Paillerets, A.Tsalamlal, R.Kumar, S.Klebe, B.Grandchamp, N.Andrieu-Abadie, L.Thomas,
A.Brice, N.Dumaz, N.Soufir)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/26683220
http://www.viartis.net/parkinsons.disease/news/151223.pdf
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©2015 Viartis
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