28th December 2015 - New research
Researchers determined the value of enhanced substantia nigra echo in the diagnosis of
Parkinson's Disease by analyzing the intensity and area of substantia nigra echo using
transcranial Doppler sonography (TCS). Transcranial Doppler sonography is a technique that
uses a handheld, microprocessor-controlled, low-frequency, pulsed Doppler transducer to
measure the velocity and pulsatility of blood flow within certain areas of the brain.
People without Parkinson's Disease were compared to people
with ultra early stage Parkinson's Disease using results of
substantia nigra echo, which are graded I (the least) to V (the
greatest). The sensitivity of substantia nigra echo in
diagnosing Parkinson's Disease was 89% and the specificity
was 93%. %). The levels were much higher in Parkinson's
Disease.
The figures for those people with Parkinson's Disease compared to those who did not have it
were Grade V (19% v none), Grade IV (33% v none), Grade III (36% v 6%), Grade II (11%
v 40%), Grade I (none v 53%). High grades were only present in Parkinson's Disease. Low
grades were only present when there was no Parkinson's Disease.
Analysis of substantia nigra echo is of practical use for the diagnosis of the ultra early stage
Parkinson's Disease, and so can potentially improve the accuracy of clinical diagnosis to
significantly enhance the early clinical prevention of disability.
information go to : http://pubs.rsna.org/doi/pdf/10.1148/radiographics.15.1.7899596
Reference : European Review of Medical and Pharmacologial Sciences [2015] 19 (23) :
4621-4626 (J.J.Zhuang, Y.H.Zheng, X.W.Xu, L.Zhou)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/26698260
http://www.viartis.net/parkinsons.disease/news/151228.pdf
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©2015 Viartis
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