18th February 2016
http://www.viartis.net/parkinsons.disease/news/160218.pdf
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| Iron Pills |
Previous studies have claimed that there is an accumulation of iron in the brains of people
with Parkinson's Disease This study was designed to explore the progressive pattern of iron
accumulation at different stages of Parkinson's Disease. They were able to confirm a
regionally progressive pattern of iron accumulation in the different stages of Parkinson's
Disease.
The substantia nigra pars compacta, which is the primary area
of the brain affected by Parkinson's Disease, showed
significantly increased iron levels in people with early
Parkinson's Disease. In people with advanced Parkinson's
Disease, the regions of the brain with higher concentrations of
iron spread to other areas of the brain (substantia nigra pars
reticulata, red nucleus, globus pallid us).
Iron accumulation occurs in Hereditary Hemochromatosis. If iron accumulation caused
Parkinson's Disease people with Hereditary Hemochromatosis should also have Parkinson's
Disease. However, very few people with Hereditary Hemochromatosis have it. Instead of
causing Parkinson's Disease, higher intake of iron is associated with a reduced risk of
Parkinson's Disease. Iron is essential for the formation of dopamine, which is deficient in
Parkinson’s Disease. It is a common compensatory mechanism for a cofactor such as iron to
accumulate when the substance it facilitates the formation of is deficient.
So instead of iron
accumulation causing Parkinson's Disease, Parkinson's Disease causes iron accumulation.
Reference : NMR in Biomedicine [2016] Feb 8 [Epub ahead of print] (X.Guan, M.Xuan,
Q.Gu, P.Huang, C.Liu, N.Wang, X.Xu, W.Luo, M.Zhang)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/26853890
http://www.viartis.net/parkinsons.disease/news/160218.pdf
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©2015 Viartis
http://www.viartis.net/parkinsons.disease/news/160218.pdf
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