6th May 2016 - New research
Bradyphrenia is mental slowness.
Bradyphrenia can consist of slowness of thought, impaired
attention and motivation, lack of spontaneity, and inflexibility. Bradyphrenia was well
known to occur in Parkinson's Disease. For the first time researchers have assessed how
prevalent bradyphrenia is in Parkinson's Disease and what causes it.
Bradyphrenia was found to occur in as many as half of people
with Parkinson's Disease. Between 11% and 51% of people
with Parkinson's Disease were found to exhibit mental
slowness by performing significantly worse on neuro-
psychological tests including tests of attention and executive
function. However, bradyphrenia was found to be uncommon
in people with Parkinson's Disease who did not also have
dementia or depression.
The results suggest that the depression or dementia that often accompanies Parkinson's
Disease is the cause of the bradyphrenia. Bradyphrenia in Parkinson's disease may also
reflect advancing age because the effects of age may be greater in some cases than the effects
of basal ganglia disease once motor dysfunction has been allowed for. However, he
dopamine system through the medial forebrain bundle projecting from the ventral tegmental
area to the nucleus accumbens, ventral striatum (limbic striatum) and the cortex is associated
with bradyphrenia.
Reference : Journal of Clinical and Experimental Neuropsychology [2016] May 1 : 1-9
[Epub ahead of print] (T.T.Vlagsma, J.Koerts, O.Tucha, H.T.Dijkstra, A.A.Duits, T.van Laar,
J.M.Spikman)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/27132647
http://www.viartis.net/parkinsons.disease/news/160506.pdf
mail@viartis.net
©2016 Viartis
http://www.viartis.net/parkinsons.disease/news/160506.pdf
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