A
genetic defect appears to accelerate the onset of Parkinson’s disease in people
aged 50 and younger, new research finds.
The
genetic mutation affects the gene that produces dopamine in the brain, and is
dramatic especially for people under the age of 50 that are Caucasian,
researchers say.
As
many as one million Americans live with Parkinson’s disease. The average age of
onset is 60 years old, but an estimated four percent of patients are diagnosed
at age 50 or younger.
According
to the Iowa State University study, people who inherit one bad version of the
gene - guanosine triphosphate cyclohydrolase-1 or GCH1 – develop Parkinson’s
disease five years earlier and are at a 23 percent increased risk for the
disease.
However,
young-to-middle-age adults with the mutation had a 45 percent increased risk of
developing Parkinson's disease. Researchers say the presence of the defective
gene in older adults had minimal effect.
The
study is the first to look at these different biological markers, as well has
how the gene's impact on dopamine production specifically affects people who
are white.
The
Iowa State study includes 289 people recently diagnosed with Parkinson's, but
not on medication, and 233 healthy people.
They
found those with the defective gene, regardless of age, were more anxious and
struggled more with daily activities. However, the defective gene was not as
strong of a predictor of developing Parkinson's in people over 50.
It is
also important to pay attention to blood cholesterol levels. The study shows
that carriers of the defective GCH1 gene had higher cholesterol than
non-carriers, which was true regardless of age, the study finds.
Cholesterol is directly related to the ability to
produce dopamine. High LDL, or what's considered "bad" cholesterol,
is an established risk factor of Parkinson's.
http://www.newsmax.com/Health/Health-News/Parkinsons-disease-genetics/2016/11/28/id/760965/
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