(HealthDay)—Parkinson's disease (PD) patients with depression have impaired white matter integrity, especially in the long contact fibers in the left hemisphere, according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.
Jia-Yong Wu, from Nanjing Medical University in China, and colleagues examined whole brain white matter integrity in 31 PD patients with depression and 37 without depression using diffusion tensor imaging.
The groups did not differ in age, gender, age of onset, disease duration, Hoehn-Yahr scale, Unified Parkinson's Disease Rating Scale scores-III, or Mini-Mental State Examination scores; only the Hamilton Depression Rating Scale (HDRS) differed between the groups. The researchers observed reduced fractional anisotropy values in the left anterior corona radiata, left posterior thalamic radiation, left cingulum, left superior longitudinal fasciculus, left sagittal stratum (including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus), and left uncinate fasciculus among PD patients with depression. There was a negative correlation for the HDRS and the fractional anisotropy value in the left cingulum and left superior longitudinal fasciculus among patients with depression (P = 0.032 and 0.025, respectively).
"These findings may be helpful for further understanding the potential mechanisms underlying depression in PD," the authors write.
https://medicalxpress.com/news/2017-12-impaired-white-depression-parkinson.html
Summary
Aims
Depression is one of the most common nonmotor symptoms in Parkinson's disease (PD). But the pathogenesis is still unclear. Studies have shown that depression in PD is closely related to the white matter abnormalities, but the number of studies is still very small and lack of whole brain white matter lesions study.
Methods
In this study, we investigated whole brain white matter integrity in 31 depressed PD patients and 37 nondepressed PD patients by diffusion tensor imaging.
Results
There was no difference in age, gender, age of onset, disease duration, Hoehn-Yahr scale, Unified Parkinson's Disease Rating Scale scores-III, and Mini-Mental State Examination scores between the two groups. The only difference was the Hamilton Depression Rating Scale. Depressed PD patients showed reduced fractional anisotropy values in the left anterior corona radiata, left posterior thalamic radiation, left cingulum, left superior longitudinal fasciculus, left sagittal stratum (including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus), and left uncinate fasciculus. In patients with depression, the Hamilton Depression Rating Scale (HDRS) was negatively correlated with the FA value in the left cingulum (r = −0.712, P = .032) and left superior longitudinal fasciculus (r = −0.699, P = .025).
Conclusions
This study suggested depression in PD was related to impaired white matter integrity especially the long contact fibers in the left hemisphere. These findings may be helpful for further understanding the potential mechanisms underlying depression in PD.
http://onlinelibrary.wiley.com/doi/10.1111/cns.12778/abstract
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