Our Parkinson's Place: ANTIEMETICS, ANTIPSYCHOTICS, ANTIDEPRESSANTS AND THE RISK OF PARKINSON'S DISEASE

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Monday, January 21, 2019

ANTIEMETICS, ANTIPSYCHOTICS, ANTIDEPRESSANTS AND THE RISK OF PARKINSON'S DISEASE

19th January 2019

Antipsychotics, antidepressants, and antiemetics are well-known causative agents of parkinsonism. However, it is not absolutely certain that the use of these medications increase the risk of Parkinson's Disease. The aim was to define the risk of Parkinson's Disease associated with use of antipsychotic, antidepressant, or antiemetic therapy.

There was an observed increased risk of Parkinson's Disease with the separate use of antiemetics of 8%. There was an observed increased risk of Parkinson's Disease with the separate use of antipsychotics of 31%. There was an increased observed risk of Parkinson's Disease with the combined use of antiemetics and antipsychototics of 42%. The use of antidepressants on their own and in combination with antipsychotics was not associated with a higher risk of Parkinson's Disease.

Separate or concurrent use of antiemetics and antipsychotics showed increased risks of Parkinson's Disease. Although statistical significance was observed, when taking into account that there are still unmeasured, unconsidered confounders, the level of statistical significance could be different.

Caution will still be needed in prescribing these drugs in people who have Parkinson's Disease.

Reference : International Journal of Clinical Pharmacology and Therapeutics [2018] 10.5414/CP203354 [Epub ahead of print] (J.Y.Shin, H.L.Jeon, H.E.Jeong, H.I.Ma, S.Jang)

Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/30526811

http://www.viartis.net/parkinsons.disease/news/190119.pdf mail@viartis.net

http://www.viartis.net/parkinsons.disease/news/190119.htm