WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Thursday, February 7, 2019

The involvement of the gut in Parkinson's disease: hype or hope?

February 7, 2019 by  



Depiction of the four most important issues that need to be addressed in the next 10 years regarding the gut in PD. Credit: Servier Medical Art, licensed under a Creative Commons Attribution 3.0 Unported License

There is growing evidence that at least in some patients with Parkinson's disease (PD), the disease may begin in the gut. Writing in a special supplement to the Journal of Parkinson's Disease, experts explore the last two decades of research about the gut-brain axis in PD and look ahead at the possible development and impact of these research areas in the next two decades.

PD is a slowly progressive disorder that affects movement, muscle control, and balance. In the last 20 years it has become clear that PD is associated with a number of gastrointestinal symptoms originating from functional and structural changes in the gut and its associated neural structures. Many patients with PD suffer from gut-related symptoms such as constipation, which have an impact on quality of life. Accumulating evidence suggests that in at least a subgroup of patients, these disturbances happen years before the development of motor symptoms and diagnosis of PD and may therefore provide important insights into the origin and development of the .

"Better understanding the role of the gut in PD will help us to understand the origin of the disease and to improve treatments," explained Filip Scheperjans, MD, Ph.D., from the Department of Neurology, Helsinki University Hospital, Helsinki, Finland, and colleagues. "There is accumulating evidence that at least in some PD patients, the origin of the disease may lie in the gut with possible involvement of abnormal protein aggregates, local inflammation, and the . Therefore, further studies into the role of the gut in PD are important and may reveal new possibilities for diagnosis and treatment."
The authors identified four key issues:
  1. Alpha-synuclein deposits are observed in the enteric nervous system (ENS) of PD patients However, it remains to be determined if the alpha-synuclein aggregates in the ENS are biochemically similar to the ones found in the brain as this might be critical in understanding the role of the gut in PD pathogenesis.
  2. Triggering of initial alpha-synuclein aggregation in enteric nerve terminals through extrinsic factors could be facilitated by intestinal hyperpermeability. It remains to be definitely demonstrated that intestinal permeability is increased in PD.
  3. Results of immunohistochemistry-based studies on alpha-synuclein deposits in the ENS of PD patients have provided conflicting results. There is therefore a critical need to develop alternative techniques to detect alpha-synuclein aggregates in the gut.
  4. Alterations of gut microbiota composition in PD have been shown in multiple cross-sectional studies from diverse populations. It will be crucial to determine the mechanisms that connect gut microbiota and PD in large multicenter studies of PD patients before and after diagnosis as well as in animal models employing multiomics approaches.
The authors predict that major advances will be made over the next 20 years in understanding the role of gastrointestinal alpha-synuclein pathology in the etiology of PD and explaining the degree of similarity between pathophysiological processes in PD and those of true prion diseases such as Creutzfeldt-Jakob disease. Accessible and affordable methods such as radio-opaque markers to assess gastrointestinal transit times will find more widespread use in future studies. They believe there is good reason to envision that gut microbiota may have important implications in the future diagnostic and therapeutic landscape of PD and that therapeutic applications based on the gut microbiome are possible through a range of approaches, including dietary interventions, probiotics, prebiotics, and fecal microbiota transplantation. And finally, that a more detailed understanding of microbiome-host-interactions in PD could identify new pathways that could be targeted using more traditional pharmacological approaches.

"Our understanding and appreciation of the importance of the gut-brain connection in PD has grown rapidly in recent years. We are confident that the coming two decades of microbiome-gut-brain-axis research will see an even accelerated development in this area that will reshape our understanding of the pathogenesis of PD," concluded Dr. Scheperjans.

"The gut has emerged as one of the new frontiers in PD research," commented Patrik Brundin, MD, Ph.D., Van Andel Research Institute, Grand Rapids, MI, USA, and J. William Langston, MD, Stanford Udall Center, Department of Pathology, Stanford University, Palo Alto, CA, USA, Editors-in-Chief of the Journal of Parkinson's Disease. "We predict there will be several advances regarding the gut in the coming 20 years. Changes in the gut might be utilized to diagnose PD earlier; new therapies targeting these changes might slow disease progression, reduce constipation, and improve gut function in patients who have already been diagnosed."

https://medicalxpress.com/news/2019-02-involvement-gut-parkinson-disease-hype.html

No comments:

Post a Comment