I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

Monday, April 11, 2016

Researchers identify tissue biomarker for dementia with lewy bodies and Parkinson's disease

New research reported in the Journal of Parkinson's Disease

THE BLACK FIBER IS POSITIVE FOR ALPHA-SYNUCLEIN PATHOLOGY INSIDE A NERVE FIBER IN THE SUBMANDIBULAR GLAND.

April 11, 2016

Amsterdam, NL, April 11, 2016 - Accurate diagnosis of Parkinson's disease, and the related disease "dementia with Lewy bodies," can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high. New research published in the Journal of Parkinson's Disease indicates that a biopsy of the submandibular gland can help identify the same pathology that is seen in the brain, providing some of the increased accuracy of brain biopsy, but not the increased risk.

Investigators had previously shown, first in autopsies and then with biopsies, that the submandibular gland, the saliva-producing gland in the neck, has the signature alpha-synuclein microscopic pathology of Parkinson's disease and that the gland can be biopsied to provide an unambiguous confirmation of diagnosis. "This new work shows, in autopsies, that the submandibular gland also has the same signature alpha-synuclein pathology in a high proportion of subjects diagnosed during life with dementia with Lewy bodies. Biopsy of the submandibular gland then also may be able to provide a more accurate diagnosis of dementia with Lewy bodies during life," explained lead investigator Thomas G. Beach, MD, PhD, Head and Senior Scientist at the Civin Laboratory for Neuropathology, Director of the Brain and Body Donation Program, Banner Sun Health Research Institute (BSHRI), Phoenix, Arizona.

Lewy-type α-synucleinopathy (LTS) is found in the brains of all Parkinson's disease patients when they are autopsied. For a number of other diseases related to Lewy bodies, this same pathology is present. This study involved subjects with central-nervous-system Lewy-type diseases and a control group without Lewy-type pathology. Both groups were comprised of elderly subjects who had volunteered for the Arizona Study of Aging and Neurodegenerative Disorders and the Brain and Body Donation Program (BBDP).

When LTS is present, it is possible to see it by using an immunohistochemical staining technique. In the image, the dark line is a nerve fiber in the submandibular gland, made visible with the stain. This finding was not observed in normal control subjects.

In this study, submandibular gland alpha-synuclein pathology was found in 42/47 (89%) of autopsies of individuals with Parkinson's disease and 20/28 (71%) of those with dementia with Lewy bodies, but in none of the 110 control subjects.

The subjects had a variety of conditions. Those with Lewy body disorders included 46 with Parkinson's disease, 28 with dementia with Lewy bodies (DLB), nine with incidental Lewy-body disease, 33 with Alzheimer's disease with Lewy bodies, and two with progressive supranuclear palsy with Lewy bodies (PSPLB). Control subjects, defined as individuals without central-nervous-system LTS, included 79 normal elderly subjects, 15 with Alzheimer's disease, 12 with progressive supranuclear palsy, two with corticobasal degeneration and two with multiple system atrophy (MSA).

In the specific case of DLB, Dr. Beach emphasized that this study is important because, "The low diagnostic accuracy, during life, for dementia with Lewy bodies, has made it difficult to conduct effective clinical trials of possibly helpful new drugs. With better diagnostic accuracy, clinical trials would have a higher chance of success and could be done more quickly and at lesser cost. The next step will be to do biopsies of the submandibular gland in living people with dementia with Lewy bodies to confirm these autopsy results."

http://www.eurekalert.org/pub_releases/2016-04/ip-rit041116.php