Research uncovers a new disruption at the root of Parkinson’s disease

6 October 2016

Patrik Verstreken (VIB-KU Leuven)

Leading-edge research by the team of professor Patrik Verstreken (VIB-KU Leuven) has shown for the first time that a malfunctioning stress-coping mechanism in the brain is at the root of Parkinson’s disease. Genetic mutations that cause Parkinson’s disease can prevent synapses – the junctions between neurons where electrical signals are transmitted – from coping with the stress of intense brain activity. This damages the synapses, which in turn disrupts the transmission of brain signals. Building on these findings, the scientists hope to correct the dysfunction and find strategies to re-establish normal synaptic communication. The results are published in the leading trade journal Neuron.

Professor Patrik Verstreken (VIB-KU Leuven) specializes in brain research, with a particular interest in synapses, the place where neurons contact one another and transmit signals. In various brain disorders – like Parkinson’s disease – communication at these synapses is impaired. The new research identifies an important cause of this disruption.

Patrik Verstreken (VIB-KU Leuven): “Synapses have to transmit an enormous amount of electrical signals. Some neurons will fire more than 800 of those signals in just one second. We have discovered that synaptic contacts have developed special mechanisms to deal with such a ‘barrage’ of signals. However, if one of these mechanisms doesn’t function properly, cellular stress is accumulated. This causes damage to the synapses and ultimately leads to neurodegeneration.”

Maintaining synaptic function 

Professor Verstreken’s team investigated different types of coping mechanisms and uncovered that one type is disrupted in Parkinson’s disease. This aberration involves different known genetic factors and affects specifically synapses. 

Patrik Verstreken (VIB-KU Leuven): “Our work is the first to implicate dysfunctional synapses so profoundly in Parkinson’s. After using mostly fruit flies to understand the disease mechanism it will now be interesting to see whether an identical stress-coping mechanism is disrupted in human patients as well. Our collaborators at the European Neuroscience Institute in Göttingen led by Ira Milosevic already made very similar discoveries in mouse neurons. In any case, this research tells us that it is absolutely critical to find strategies to maintain synaptic function in treating this disease.”

 

Future research

Building on the results of this research, the scientists want to find out how universal the stress-coping mechanism is disrupted in Parkinson’s disease. 

Patrik Verstreken (VIB-KU Leuven): “Next, we hope to correct the dysfunction caused by the Parkinson mutations and identify strategies that might re-establish normal synaptic communication. Reactivation of the coping mechanism, for instance, might also repair the damaged synapses. Of course, this requires additional research.”

Publication
A LRRK2-dependent EndophilinA phosphoswitch is critical for macroautophagy at presynaptic terminals, Neuron 2016

Questions from patients
A breakthrough in research is not the same as a breakthrough in medicine. The realizations of VIB researchers can form the basis of new therapies, but the development path still takes years. This can raise a lot of questions. That is why we ask you to please refer questions in your report or article to the email address that VIB makes available for this purpose: patienteninfo@vib.be. Everyone can submit questions concerning this and other medically-oriented research directly to VIB via this address

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