IRVINE, CALIF. MRI Interventions, Inc. (OTCQB:MRIC) today announced that Dr. Mark Richardson performed his 75th real-time, MRI guided neurosurgical procedure utilizing the ClearPoint® Neuro Navigation System at the University of Pittsburgh Medical Center (UPMC). “The ClearPoint Neuro Navigation System provides me with real-time visualization for precision planning, navigating and placement of electrodes, laser ablation fibers, biopsy needles and now drug delivery,” stated Dr. Mark Richardson, MD, PhD, FAANS, Director of Epilepsy and Movement Disorders at UPMC Presbyterian. "Recently, we were selected to participate in a novel drug delivery trial, for the treatment of Parkinson’s Disease." The trial, sponsored by Voyager Therapeutics, is investigating the safety of increasing AADC levels in the putamen via gene delivery for the treatment of Parkinson’s Disease. The investigational drug termed VY-AADC01, is comprised of the adeno-associated virus-2 capsid and a cytomegalovirus promotor to drive AADC transgene expression. When delivered directly to the putamen where the dopamine receptors are located, the drug is designed to enable the neurons of the putamen to express the AADC enzyme to convert levodopa into dopamine. “Utilizing the ClearPoint Neuro Navigation System, we can monitor the therapy throughout the infusion and make adjustments as required to maximize coverage of the putamen. The ability to watch the drug infuse into the target tissue under real-time, MRI guidance is critical to the success of the overall therapy.”
The ClearPoint System, together with the SmartFlow® Cannula provide a complete, real- time, MRI guided Convection Enhanced Delivery (CED) solution for planning, navigation, and delivery of therapeutic agents. In addition, patients under general anesthesia do not have to endure the placement of a large stereotactic headframe which improves patient comfort. The ClearPoint System is now being utilized as the navigation and planning system for several pre-clinical and clinical drug delivery trials with multiple biotech and pharmaceutical partners. These trials are addressing significant diseases such as Parkinson’s Disease, Huntington’s Disease, and brain tumors. By enabling the surgeon to see the infusion of the therapeutic into the target brain tissue in real time, the ClearPoint System is becoming the navigation and delivery technology of choice for leading edge therapeutic programs.
About MRI Interventions, Inc.
Building on the imaging power of MRI, MRI Interventions is creating innovative platforms for performing the next generation of minimally invasive surgical procedures in the brain. The ClearPoint System, which has received 510(k) clearance and is CE marked, utilizes a hospital’s existing diagnostic or intraoperative MRI suite to enable a range of minimally invasive procedures in the brain. For more information, please visit www.mriinterventions.com.
https://www.dotmed.com/news/story/33530
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