Summary: Study suggests loss of blood vessels in retina reflect changes in brain health
Source: Duke University Medical Center
A quick eye exam might one day allow eye doctors to check up on both your eyeglasses prescription and your brain health.
A study of more than 200 people at the Duke Eye Center published March 11 in the journal Ophthalmology Retina suggests the loss of blood vessels in the retina could signal Alzheimer’s disease.
In people with healthy brains, microscopic blood vessels form a dense web at the back of the eye inside the retina, as seen in 133 participants in a control group.
In the eyes of 39 people with Alzheimer’s disease, that web was less dense and even sparse in places. The differences in density were statistically significant after researchers controlled for factors including age, sex, and level of education, said Duke ophthalmologist and retinal surgeon Sharon Fekrat, M.D., the study’s senior author.
New research from Duke Eye Center suggests loss of blood vessels in the retina could signal Alzheimer’s disease. On the left, the retina of a healthy person shows a dense web of blood vessels, the highest-density areas highlighted in red and orange. On the right, the retina of a person with Alzheimer’s disease shows areas in blue and teal where blood vessels are least dense. The images were captured using optical coherence tomography angiography (OCTA). The full study appears March 11 in the journal Ophthalmology Retina. Credit: Duke Eye Center
“We’re measuring blood vessels that can’t be seen during a regular eye exam and we’re doing that with relatively new noninvasive technology that takes high-resolution images of very small blood vessels within the retina in just a few minutes,” she said. “It’s possible that these changes in blood vessel density in the retina could mirror what’s going on in the tiny blood vessels in the brain, perhaps before we are able to detect any changes in cognition.”
The study found differences in the retinas of those with Alzheimer’s disease when compared to healthy people and to those with mild cognitive impairment, often a precursor to Alzheimer’s disease.
With nearly 6 million Americans living with Alzheimer’s disease and no viable treatments or noninvasive tools for early diagnosis, its burden on families and the economy is heavy. Scientists at Duke Eye Center and beyond have studied other changes in the retina that could signal trouble upstream in the brain, such as thinning of some of the retinal nerve layers.
“We know that there are changes that occur in the brain in the small blood vessels in people with Alzheimer’s disease, and because the retina is an extension of the brain, we wanted to investigate whether these changes could be detected in the retina using a new technology that is less invasive and easy to obtain,” said Dilraj S. Grewal, M.D., a Duke ophthalmologist and retinal surgeon and a lead author on the study. The Duke study used a noninvasive technology called optical coherence tomography angiography (OCTA). OCTA machines use light waves that reveal blood flow in every layer of the retina.
An OCTA scan could even reveal changes in tiny capillaries — most less than half the width of a human hair — before blood vessel changes show up on a brain scan such as an MRI or cerebral angiogram, which highlight only larger blood vessels. Such techniques to study the brain are invasive and costly.
“Ultimately, the goal would be to use this technology to detect Alzheimer’s early, before symptoms of memory loss are evident, and be able to monitor these changes over time in participants of clinical trials studying new Alzheimer’s treatments,” Fekrat said.
In addition to Fekrat and Grewal, study authors include Stephen P. Yoon, Atalie C. Thompson, Bryce W. Polascik, Cynthia Dunn and James R. Burke.
Source:
Media Contacts:
Samiha Khanna – Duke University Medical Center
Image Source:
The images were captured using optical coherence tomography angiography (OCTA). The full study appears March 11 in the journal Ophthalmology Retina. Duke Eye Center
Original Research: Paywalled
Presented at: Association for Research in Vision and Ophthalmology Annual Meeting, April–May 2018, Honolulu, Hawaii; Duke Residents’ and Fellows’ Day, June 2018, Durham, North Carolina; and American Academy of Ophthalmology Annual Meeting, October 2018, Chicago, Illinois.
Ophthalmology Retina
Yoon, Stephen P. et al.
Funding:
Financial Disclosure(s): The author(s) have made the following disclosure(s): D.S.G.: Financial support – Allergan, Alimera.
Supported in part by the National Institutes of Health, Bethesda, Maryland (grant no.: P30EY005722); Research to Prevent Blindness, Inc, New York, New York (unrestricted grant to Duke University); and the Karen L. Wrenn Alzheimer’s Disease Award, Durham, North Carolina. None of the funding agencies had any role in the design or conduct of this research.
https://neurosciencenews.com/alzheimers-disease-eye-test-octa-retina-10876/
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