WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Monday, April 29, 2019

FoxFeed Blog: What We Fund: $5 Million in New Grants for Parkinson's Research

Posted by  Maggie McGuire Kuhl,   April 29, 2019






The Michael J. Fox Foundation for Parkinson's Research (MJFF) announces 39 new grant awards totaling more than $5 million. The selected projects reflect our research strategy to define, measure and treat Parkinson's disease. We also awarded grants to help develop the research tools the field needs to advance.
All of our funding decisions serve our mission to find a cure for Parkinson's and improved treatments for those living with the disease today. Each research step -- from laboratory studies to understand the disease through clinical trials of potential drugs to stop it -- is designed to support those goals. Highlights of the studies that received our latest grants follow. For more information on recent MJFF-supported projects, visit our funded grants page.
Define


We seek to understand the causes of Parkinson's, its progression and the factors that account for the variability of the disease. We recently issued six new grants in this area at a total of $1,535,131.

  • Two projects are investigating the GBA gene. Mutations in this gene are linked to Parkinson's disease. Bahareh Behrouz, PhD, at biotech company NeuroInitiative LLC is using computers to simulate how GBA and another Parkinson's-associated gene, LRRK2, may interact. Her team also will test if therapeutic strategies against these targets may work in people without these mutations. Avner Thaler, MD, PhD, at Tel Aviv Sourasky Medical Center is looking at inflammation in people with a GBA mutation, those with Parkinson's and at-risk mutation carriers. Higher inflammation levels in these populations could lead to therapies to ease symptoms and perhaps even prevent disease onset.
  • Other projects are looking at another priority target: the alpha-synuclein protein. Nearly everyone with Parkinson's has clumps of alpha-synuclein, which scientists believe is toxic to cells. Robert H. Edwards, MD, at the University of California, San Francisco will examine how rare genetic mutations change the function of alpha-synuclein. That understanding could help direct treatments to correct or offset that dysfunction, including in people without those mutations.
Measure


MJFF funds the discovery of methods to diagnose Parkinson's, measure its progression and assess the effectiveness of treatments for it. We recently supported 19 new projects in this area with a total of $2,119,440.

  • Two grants are supporting projects using imaging techniques to measure Parkinson's disease. Robert Mach, PhD, at the University of Pennsylvania is developing an imaging agent to visualize the Parkinson's-implicated protein alpha-synuclein in the living brain. We also have issued a supplemental grant to Neil Vasdev, PhD, at MedChem Imaging LLC for his work testing imaging tools to measure synapses, structures in the brain that allow nerve cells to communicate with other cells.
  • Yuanfang Guan, PhD, at the University of Michigan will apply and develop deep learning models to interpret data collected from wearable devices. Deep learning teaches computers to recognize and classify items. It's how Apple's Siri or Amazon's Alexa can recognize and respond to your words, for example. These models could help measure movement and disease progression with smartphones and smartwatches.
  • Another funded project is pursuing a Parkinson's measure in urine, a sample easy to obtain frequently and over time (as compared to spinal fluid, for example). Kendall Van Keuren-Jensen, PhD, from the Translational Genomics Research Institute is measuring and analyzing RNA, our gene's messengers, in urine from control volunteers, people with Parkinson's and people with Alzheimer's disease. Finding Parkinson's-specific RNA changes in urine could lead to an easily accessible test for Parkinson's and more information on the effect of the disease.
Treat


These awards directly fund the development of treatments to slow or stop Parkinson's and alleviate its symptoms. We recently gave two new grants in this area at a total of $514,506.

Tools


We ensure the field has the research tools it needs to advance, such as assays, cells lines, and DNA plasmids. We recently supported 12 new projects in this area with a total of $1,286,187.

  • This round of grants supported a number of projects developing research tools around key Parkinson's targets such as alpha-synuclein and inflammation.
  • It also included support for Fox BioNet, a consortium of centers mobilized to quickly collect biological samples for studies that aim to measure specific proteins and pathways implicated in Parkinson's disease.
https://www.michaeljfox.org/foundation/news-detail.php?what-we-fund-million-in-new-grants-for-parkinson-research-b

No comments:

Post a Comment