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Friday, September 27, 2019

A model for brain activity during brain stimulation therapy

SEPTEMBER 27, 2019    by University of Pennsylvania





Graphical Abstract Optimizing direct electrical stimulation for the treatment of neurological disease remains difficult due to an incomplete understanding of its physical propagation through brain tissue. Here, we use network control theory to predict how stimulation spreads through white matter to influence spatially distributed dynamics. We test the theory’s predictions using a unique dataset comprising diffusion weighted imaging and electrocorticography in epilepsy patients undergoing grid stimulation. We find statistically significant shared variance between the predicted activity state transitions and the observed activity state transitions. We then use an optimal control framework to posit testable hypotheses regarding which brain states and structural properties will efficiently improve memory encoding when stimulated. Our work quantifies the role that white matter architecture plays in guiding the dynamics of direct electrical stimulation and offers empirical support for the utility of network control theory in explaining the brain’s response to stimulation. DOI:https://doi.org/10.1016/j.celrep.2019.08.008


Brain stimulation, where targeted electrical impulses are directly applied to a patient's brain, is already an effective therapy for depression, epilepsy, Parkinson's and other neurological disorders, but many more applications are on the horizon. Clinicians and researchers believe the technique could be used to restore or improve memory and motor function after an injury, for example, but progress is hampered by how difficult it is to predict how the entire brain will respond to stimulation at a given region.

In an effort to better personalize and optimize this type of therapy, researchers from the University of Pennsylvania's School of Engineering and Applied Science and Perelman School of Medicine, as well as Thomas Jefferson University Hospital and the University of California, Riverside, have developed a way to model how a given patient's  will change in response to targeted .

To test the accuracy of their model, they recruited a group of study participants who were undergoing an unrelated treatment for severe epilepsy, and thus had a series of electrodes already implanted in their brains. Using each individual's brain activity data as inputs for their model, the researchers made predictions about how to best stimulate that participant's brain to improve their performance on a basic memory test.
The participants' brain activity before and after stimulation suggest the researchers' models have meaningful predictive power and offer a first step towards a more generalizable approach to specific stimulation therapies.
The study, published in the journal Cell Reports, was led by Danielle Bassett and Jennifer Stiso, a neuroscience graduate student and a member of Bassett's Complex Systems Lab.
Memory is just one area where electrical stimulation therapy is thought to have promise, but more basic research on how to coax brain activity into the desired state is needed.
"There are patterns of activity across the entire brain when you're remembering something, and those patterns look different depending on how well you're doing," Stiso says. "We know electrical stimulation can change those patterns, but how to change them into the pattern associated with better performance isn't clear."
With a collaboration between neurologists at the Hospital for the University of Pennsylvania and Thomas Jefferson University Hospital, the researchers found epilepsy patients with implanted electrodes who were willing to volunteer to receive targeted stimulation during direct brain recordings while they awaited surgery.
While their brain activity was being recorded, the patients participated in basic memory tests, which entailed hearing and recalling a list of words.
"We then used features of those individuals' brain activity, and the pattern of connections between their brain regions, to model what would happen to the whole brain when we stimulate a specific region," Stiso says. "A lot of memory research is focused on specific regions of the brain, like the hippocampus, but we think these therapies need to take a much larger network of regions into account."
Combined with data from other stimulation experiments conducted with these epilepsy patients, these models suggested which specific patterns of brain activity and connections would be most beneficial when the stimulation was targeted to improve memory.
"Using in silico experiments, we found that stimulation that had been optimized based on the model pushed the brain towards states of good  performance," says Bassett.
"Ultimately, we're trying to figure out where and how much to stimulate each person's brain to reach the -wide patterns associated with the specific goal of a given therapy," Stiso says. "This type of study is an important, early step towards developing a fast, generalizable  of an individual's response to a specific stimulation ."
More information: Jennifer Stiso et al. White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions, Cell Reports (2019). DOI: 10.1016/j.celrep.2019.08.008
Journal information: Cell Reports
https://medicalxpress.com/news/2019-09-brain-therapy.html

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