It is often claimed that alpha-synculein is a hallmark of Parkinson's Disease or indicates its
severity. It has even been wrongly claimed to be the primary cause of Parkinson's Disease.
However, it has instead been found to be related to the cognitive decline that can occur in
Parkinson's Disease, especially as Parkinson's Disease worsens.
Plasma levels of alpha-synuclein were much higher in people with
Parkinson's Disease. However, although there was a significant
increase in plasma alpha-synuclein levels in people with
Parkinson's Disease, in later stages of Parkinson's Disease there
was no correlation with motor symptom severity, as assessed by
Unified Parkinson's Disease Rating Scale part III scores (the main
Parkinson's Disease symptom score).
However, plasma alpha-synuclein levels were significantly higher in people with Parkinson's
Disease who had dementia than in people with Parkinson's Disease who only had mild
cognitive impairment or normal cognition.
The results suggest that plasma alpha-synuclein levels correlate with cognitive decline but
not with motor severity in people with Parkinson's Disease. Plasma alpha-synuclein could
therefore serve as a biomarker for people with Parkinson's Disead at risk of cognitive decline.
Reference : Journal of Neurology, Neurosurgery and Psychiatry [2017] 88 (10) : 818-824
(C.H.Lin, S.Y.Yang, H.E.Horng, C.C.Yang, J.J.Chieh, H.H.Chen, B.H.Liu, M.J.Chiu)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/28550072
http://www.viartis.net/parkinsons.disease/news/170930.pdf
mail@viartis.net
©2017 Viartis
http://www.viartis.net/parkinsons.disease/news/170930.pdf
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