Our Parkinson's Place: A BRAIN INJECTION OF DNA COULD HELP CONTROL PARKINSON'S DISEASE SYMPTOMS

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Monday, August 22, 2016

A BRAIN INJECTION OF DNA COULD HELP CONTROL PARKINSON'S DISEASE SYMPTOMS

By Kate Baggaley
Aug. 22, 2016

GENE THERAPY WOULD MAKE DRUGS EFFECTIVE LONGER

An illustration of levodopa, a drug used to treat Parkinson's disease. A biotech company is using DNA injections to help levodopa stay effective in people with advanced Parkinson's.

A biotech company wants to fight Parkinson’s disease with a shot of healthy DNA. Voyager Therapeutics is developing a form of gene therapy that could make drugs that have lost their edge work again in people with advanced Parkinson’s.

In Parkinson’s disease, neurons responsible for making the chemical messenger dopamine die. This leads to tremors, slowness, and rigidness. Currently, people with Parkinson’s can take a drug called levodopa, or L-Dopa, to control their symptoms. But L-Dopa becomes less effective with time, as the brain loses an enzyme that converts the drug into dopamine.

With gene therapy, researchers can transplant DNA that codes for this missing enzyme. During the treatment, viruses carrying this DNA are injected into a patient’s brain through a pressurized tube.

Voyager is currently testing whether the new method can deliver enough DNA to the right brain areas to restore L-Dopa’s effectiveness.

[via MIT Technology Review]

http://www.popsci.com/brain-injection-dna-could-help-people-with-parkinsons-control-their-symptoms?dom=rss-default&src=syn