27th August 2016 - New research
Recent studies have reported that peripheral neuropathy is common in people with
Parkinson's Disease and raised the possibility that L-dopa neurotoxicity is the main culprit.
Peripheral neuropathy develops when nerves in the body's extremities, such as the hands, feet
and arms, are damaged. This can cause numbness and tingling in the feet or hands, burning
pain in affected areas, and muscle weakness, especially in the feet. For more information go
to :
http://www.nhs.uk/Conditions/Peripheral-neuropathy/Pages/Symptoms.aspx
In people with Parkinson's Disease, neuropathy screening was carried out, including
neurological examination, nerve conduction studies and skin wrinkling tests.
Two of the tests showed that 57% and 42% of people
with Parkinson's Disease had abnormal results that
indicated polyneuropathy. The prevalence in people with
a Parkinsonism was similar to people with Parkinson's
Disease but the results were less severe. The results
showed that polyneuropathy was more common in
Parkinson's Disease than previously assumed, but the
cause was not solely attributed to taking L-dopa.
The researchers concluded that large fiber and small fiber polyneuropathy are common in
people with Parkinson's Disease. However, instead of concluding that the cause was L-dopa,
the cause of the neuropathy was thought to be multifactorial. Neuropathy was previously
related to age, vitamin B12 deficiency, serum folate levels, and especially L-dopa use.
Reference : BMC Neurology [2016] 16 : 139 (D.F.de Araújo, A.P.de Melo Neto, I.S.
Oliveira, B.S.Brito, I.T.de Araújo, I.S.Barros, J.W.Lima, W.G.Horta, FdeA.Gondim)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/27530902
http://www.viartis.net/parkinsons.disease/news/160827.pdf
mail@viartis.net
©2016 Viartis
http://www.viartis.net/parkinsons.disease/news/160827.pdf
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