In an international study at 17 MRI centers in the U.S., Austria and Germany, a research team led by UF's David Vaillancourt, Ph.D., used a non-invasive MRI method with 1,002 patients to develop an automated system to accurately diagnose Parkinson's disease and related but different neurodegenerative disorders.
In the study published Aug. 27 in The Lancet Digital Health, researchers used diffusion-weighted MRI, an imaging method that measures how water molecules diffuse in the brain and is particularly helpful in identifying where neurodegeneration is occurring.
Parkinson's disease and related disorders, such as multiple system atrophy and progressive supranuclear palsy, can present a challenge for accurate diagnosis because of shared and overlapping motor and non-motor symptoms. In fact, according to the new study, accuracy of diagnosis in early Parkinson's is about 58 percent, and more than half of misdiagnosed patients actually have multiple system atrophy or progressive supranuclear palsy.
The new results demonstrate the effectiveness of an automated method to provide a differential diagnosis of the various forms of Parkinson's.
"Our method may help to reduce the number of misdiagnosed cases in the future," said Vaillancourt, professor and chair of applied physiology and kinesiology and a member of the MBI Executive Committee. "Since these diseases require unique treatment plans and different medications, and clinical trials testing new medications require the correct diagnosis, getting it right is important for patient care."
More information: Derek B Archer et al. Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study, The Lancet Digital Health (2019). DOI: 10.1016/S2589-7500(19)30105-0
Journal information: The Lancet
Provided by University of Florida
https://medicalxpress.com/news/2019-08-automated-non-invasive-mri-accurately-parkinson.html
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