- Bacteriophages caused a depletion of several gut microbiome species in the PD patients compared to the control group. The most pronounced change was a 10-fold decrease in Lactococcus. Reduction of Lactococcus is particularly relevant, as they are known to be a source of microbiota-derived neurochemicals including dopamine and reductions in prevalence are associated with increased gut permeability.
- Unlike the control group, patients with PD had elevated levels of strictly virulent, lytic Lactococcus phages that caused a significant shift in relative abundance of Lactococcus bacteria.
- Researchers concluded that bacteriophages altered the microbiota of patients, leading to functional shifts that may be implicated in the pathogenesis of PD.
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Tuesday, July 17, 2018
Parkinson’s Disease Pathogenesis may have a Bacterial Virus Component According to Research Conducted by Human Microbiology Institute
- Where the nerves extending into the heart muscle were damaged;
- Where the heart tissue was experiencing the most inflammation; and
- Where they found the most oxidative stress.
New grant offering signals increased role for infectious diseases specialists researching Alzheimer’s causation
Dr. Leslie Norins, an Emeritus member of the Infectious Diseases Society of America, is funding two grants to help researchers explore germs in Alzheimer's.
What is an abstract?
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