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I have Parkinson's diseases and thought it would be nice to have a place where the contents of updated news is found in one place. That is why I began this blog.
I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible.
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Saturday, September 20, 2014
|Parkinson's patient and activist John Krumbholz of Cedar Rapids, Iowa takes a walk. A new study shows walking can reduce the symptoms of Parkinson's disease.|
Friday, September 19, 2014
Lancet Neurology  13 (8) : 767-776 (R.A.Hauser, C.W.Olanow, K.D.Kieburtz, E.
Pourcher, A.Docu-Axelerad, M.Lew, O.Kozyolkin, A.Neale, C.Resburg, U.Meya, C.Kenney,
S.Bandak) Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/25008546
Clinical trials assessed the use 60mg, 120mg, 180mg, or 240mg tozadenant in people with
Parkinson's Disease who were being treated with L-dopa and who had motor fluctuations that involved at least 2·5 hours off-time per day. Tozadenant (SYN115) is an inhibitor of the adenosine 2a (A2a) receptor that is being developed for the treatment of Parkinson's Disease.
Compared with the use of a placebo, daily off-time was reduced by more than an hour when taking either 120mg or 180mg tozadenant. The most common adverse events were dyskinesia (16% of people taking 120mg, 20% of people
taking 180mg), nausea (11% of people taking 120mg, 12% of people taking 180mg), dizziness (5% of people taking 120mg, 13% of people taking 180mg). Tozadenant, 60 mg twice daily, was not associated with a significant reduction in off-time. Tozadenant, 240 mg twice daily, was associated with an increased rate of discontinuation because of adverse events that occurred in 20% of people taking that dosage. The researchers concluded that Tozadenant at 120 or 180 mg twice daily was generally well tolerated and was effective at reducing off-time. Further investigation of tozadenant treatment in phase 3 trials is warranted.
For more information go to Biotie Therapies :
Tozadenant (SYN115): A highly differentiated product for Parkinson’s disease