December 30, 2017 by: Rhonda Johansson
Welcome to Our Parkinson's Place
I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible. I have Parkinson's diseases as well and thought it would be nice to have a place where updated news is in one place. That is why I began this blog.
I am not responsible for it's contents, I am just a copier of information searched on the computer. Please understand the copies are just that, copies and at times, I am unable to enlarge the wording or keep it uniformed as I wish. This is for you to read and to always keep an open mind.
Please discuss this with your doctor, should you have any questions, or concerns. Never do anything without talking to your doctor. I do not make any money from this website. I volunteer my time to help all of us to be informed. Please No advertisers, and No Information about Herbal treatments. Please no advertisements.
This is a free site for all.
Sunday, December 31, 2017
By Elizabeth Hernandez - December 31, 2017
Dawn Patrol made commitment to run up Flagstaff Mountain
Gary Sobol, organizer of the running group The Dawn Patrol, stands at the Chautauqua Trail on Friday in Boulder. (Jeremy Papasso / Staff Photographer)
For the past 40 New Year's Days, a group of Boulder athletes have risen early, shaking off the past year and embracing the next with a ceremonial jaunt up Flagstaff Mountain.
Gary Sobol hasn't missed a year.
The 78-year-old Boulderite still organizes the self-named "Dawn Patrol" crew and meets the gang at the top of the mountain, although Parkinson's disease has led to Sobol driving part of the way rather than the usual group run.
"I'm the only one who's made it every year," he said of the crew, which fluctuates between around a dozen to 30 people depending on the weather. "With Parkinson's disease, it's very hard to go, but with the help of my adorable wife, who sticks right with me, we get to the top together. We take a little shortcut now, but we're up there and greet the first runner."
Sobol and his family moved to Boulder in 1976.
"I was overweight and out of shape, so I started running," he said.
Exercise introduced Sobol to some local runners and hikers who decided they'd run up Flagstaff Mountain on New Year's Day to start the year off on the right frigid foot in 1977.
"We made a commitment: we would return every New Year's Day, regardless of anything else," he said. "It was kind of comical."
That first year, Sobol recalled just two people showed up for the run at the meeting spot in Basemar Shopping Center — in part, because he said it was 20 degrees below zero.
"By the time we got to the Flagstaff House restaurant, my friend had icicles hanging off his hat," he said.
Icicle hats or not, folks kept showing up every year in bigger quantities as word-of-mouth of the healthy Boulder tradition spread.
Some ran, some biked, others hiked and some walked up from the Chautauqua Trailhead, gabbing along the way until they all met at the top for a celebration.
Longtime Dawn Patrol member Martha Eskesen said back in the group's glory days, they used to tote champagne and "scrappy, little fireworks" to the top.
"I haven't seen champagne up there in awhile, though," Eskesen said. "And, obviously, no more fireworks."
When the Dawn Patrol reaches the ground again, they all head to breakfast at the Egg and I to feast and chatter.
"This group has been through a lot," said Sue Brown, Sobol's daughter. "Marriages, divorces, illnesses. My dad has had three bouts of cancer and Parkinson's disease. Through it all, they're still together."
Sobol estimates he and the crew spend four hours of their morning — from base to summit to breakfast — catching everyone up on their years.
"We show up and get out of the car and, because our lives get very busy, from that moment on, we're just talking," he said. "It's the camaraderie I love —- the friendships."
Eskesen takes pride in being the first female member of the group when she joined in 1985. When Eskesen's sister, who worked with Sobol, heard about his athletic endeavors, she knew she had to invite her sporty younger sister to show up the men.
"My sister made some kind of dare to these guys that her little sister could leave them in the dust," Eskesen said. "I started biking with them every weekend, and then they invited me to join on New Year's Day."
Eskesen has delighted in Sobol's competitive zings that motivate everyone to keep going up the mountain.
Some years stand out to members of the crew. Sobol and Eskesen both remember the year 2000 when the crew decided to run up Flagstaff at night.
"We assembled at 10:30 at night with flashlights for the millennium," Sobol said.
Eskesen reflected on particularly cold, icy, snowy years. She laughed, noting that even though the crew arrives at 9 a.m., "it is Boulder, after all," and, surely, someone will have cleared the trail a little bit before them.
"We strap on our snowshoes and do it," she said. "We'd wade through very deep snow. We've all gotten older, and our abilities have changed, but we all still get together and do it."
Brown even modifies her New Year's Eve plans to make sure she's ready to join her dad and the rest of the Dawn Patrol bright and early.
"We try to make sure we're home at a decent time, so we're not hungover or anything," she said.
Brown finds the tradition inspirational on many fronts. Beginning the year with a reminder to stay healthy and active is a plus, but her father's commitment to the event is what really warms her heart.
"Not only has he had all these physical struggles, but he has kept this group together," she said. "They're all really close friends, and it's impressive."
December 31, 2017 by Ethan Baron, The Mercury News
A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI
One Bay Area company aims to provide answers.
Mountain View's 23andMe, which sells personal DNA-testing kits, has announced a large-scale study intended to uncover the genetic reasons why diet and exercise have different effects on different people.
The company said it will recruit for the study 100,000 of its customers who are overweight, but in otherwise good health. Scientists know lifestyle, environment and genetics all play a role in a person's weight, but how those influences work together is poorly understood, 23andMe said.
"We'd like to better understand the genetic, demographic, psychosocial and behavioral characteristics that predict weight loss success overall, and on different lifestyle interventions," said Liana Del Gobbo, 23andMe's lead scientist on the study. "This will help us begin to pave the way toward more personalized lifestyle recommendations."
The company, co-founded in 2006 by entrepreneur Anne Wojcicki, biologist Linda Avey and business executive Paul Cusenza, called the 100,000-participant size of its study "unprecedented" and said researchers would look into "the effectiveness of using different diets or exercise to lose weight."
Participants' complete sets of DNA will be studied, to tease out genetic variations that may affect physical responses to diet and exercise.
Previous genetics-based research has focused on the body mass index—which uses gender, height and weight to try to quantify body fat levels—but none has explored "behavioral weight loss," which largely revolves around diet and exercise, according to 23andMe.
"This is important because the genetic variants that influence BMI may not be the same as those that influence weight loss," the company said.
Participants in the study—recruited from existing customers who have already agreed to be research subjects—will be randomly assigned to one of three regimes: One group will shun carbohydrates, one will eat more fiber but avoid animal fat, and one will eat as usual but add exercise, according to the MIT Technology Review.
"They'll report back to the company about how often they have 'cravings,' whether they're stressed, and if they succeed in following the diets," according to the Technology Review. "The company thinks that people, on average, will have roughly the same results on all the plans. What it may be able to figure out, though, is whether there are genetic or personal reasons why some individuals will end up losing 40 pounds, and others gaining 10, no matter which advice they follow."
While 23andMe's DNA-testing kits are popular among consumers, they have also attracted criticism.
"It is a mechanism meant to be a front end for a massive information-gathering operation against an unwitting public," New York University professor and science journalist Charles Seife wrote in Scientific American in 2013.
The company did not respond immediately to a request for an explanation about how it uses customers' data or whether it sells any of that data to third parties.
However, 23andMe has clearly conducted work in the public interest, including Parkinson's disease research in collaboration with the U.S. National Institutes of Health and South San Francisco's Genentech, which found 17 new genetic variants linked to the often devastating affliction, according to a paper published in the journal Nature in September.
Journal reference: Nature
31st December 2017
Delayed gastric emptying can impair absorption of L-dopa, thereby contributing to motor fluctuations. Camicinal (GSK962040), is a gastroprokinetic, which is being assessed for its effect on the absorption of L-dopa and the symptoms of Parkinson’s Disease. Gastroprokinetic drugs increase the movement of ingested material through the GI tract.
Patients were given either 50mg camicinal daily for 7 to 9 days or were taking a placebo. Average time to reach maximum L-dopa concentration by taking camicinal was reduced, indicating more rapid absorption of L-dopa. Camicinal resulted in significant reduction in OFF time, reducing it by 2 hours 18 minutes. There was a significant increase in ON time, increasing it by 1 hour 52 minutes. There was also a significant decrease in mean total MDS-UPDRS score (Parkinson’s Disease symptoms). Camicinal treatment was generally well tolerated.
Parkinson’s Disease symptom improvement with the use of camicinal occurred in parallel with a more rapid absorption of L-dopa. This study provides evidence of an improvement of the motor response to L-dopa in people with Parkinson’s Disease treated with camicinal.
Reference : Movement Disorders  Dec 26 [Epub ahead of print] (S.L.Marrinan, T.Otiker, L.S.Vasist, R.A.Gibson, B.K.Sarai, M.E.Barton, D.B.Richards, P.M.Hellström, D.Nyholm, G.E.Dukes, D.J.Burn)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/29278279
December 31, 2017
By Jenna Fletcher
By Jenna Fletcher
What are the stages of Parkinson's?
Signs and symptoms
Unified Parkinson's Disease Rating Scale (UPDRS)
Hoehn and Yahr stages
How does Parkinson's progress?
Stuart Thompson - December 29, 2017
Skipton Branch Parkinson’s UK are starting new exercise classes Picture by Stephen Garnett