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I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible. I have Parkinson's diseases as well and thought it would be nice to have a place where updated news is in one place. That is why I began this blog.
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Friday, November 24, 2017
By Brittany Murray in News | November 24, 2017
MORGANTOWN, W.Va. — WVU’s newest director of the Rockefeller Neurosciences Institute is bringing with him new tools and clinical trials to target the state’s opioid epidemic.
Dr. Ali Rezai outlined the newest advances in fighting neurological diseases, including opioid addiction, in a presentation during WVU’s third annual Academic Media Day on Nov. 13 — only 10 days after taking his position.
“There’s been tremendous advances in brain imaging and how we can visualize brain disorders,” Rezai said. “We’re able to understand the science of addiction even better than before.”
Prior to coming to WVU, Rezai served as director of Ohio State University’s Wexner Medical Center’s Neurological Institute, where he was involved in pioneering the use of brain pacemakers for treating Parkinson’s disease, depression, obsessive compulsive disorder and traumatic brain injury.
Now at WVU’s Rockefeller Neurosciences Institute, he hopes to continue that research to use the technology to treat addiction. Some of the developments could be rolling out as early as next year, unlike anything West Virginians have had access to before.
“There have been brain implants for alcohol in Europe, but we’re going to be starting a new study looking at brain implants for addiction,” Rezai said. “There’s a lot of work being done with external modulation with magnets and external electrical stimulations for addictions.”
Rezai said the goal would be to use ultrasound-based neuromodulation for addictions and develop a protocol for brain implant for severe addictions.
“Implants aren’t for the initial phase of addiction,” he said. “These are for patients who have had all the therapies done and have failed and are very disabled.”
In order to meet these goals, WVU will be partnering with many other institutions and companies to explore other technology, such as virtual reality technology, micropellet technology, magnetic stimulation and electrical stimulation technology.
“So we’ll become a rapid research and development kind of effort, so we can help patients very quickly,” Rezai said. “That’s our goal — having a very quick way of helping those afflicted with neurological conditions from chronic pain, to addictions, to Alzheimer’s, to autism, to stroke and many others.”
Micropellets, which are non-steroid, non-opioid medications, would be inserted into the body post-surgery as a pain relief to block addiction at the root before it even begins.
“First dose (of an opioid) you take, your brain changes, the chemistry of your brain changes, so this can lead to addictive behavior over time. Not everybody becomes addicted, but a certain example of the population can get addicted,” Rezai said. “So the goal is to not give the Oxycodone and narcotics or these addictive medications and instead give them local treatment, such as this micropellett that delivers the medication locally without the need to take a pill that gets systemically, that gets absorbed and goes to your brain and can make you more addicted.”
For addictions milder than those needing implants, research is also looking at external, wearable technology to track the sensors in the brain that cause addiction.
“When you’re craving or you’re seeking medications or drugs, the body’s physiology is off and is making you seek the drugs,” Rezai said. “The part of the brain that controls addictions, sends signals to the rest of the body in terms of anxiety, in terms of changes in blood vessels, in terms of changes of your heart rate varibility. There’s a number of elements or signals that go from the brain to the rest of the body.”
The goal, Rezai said, would be to detect those signals before a patient even takes the drug occurs and correlate those signals to the behavior.
“The more we can do the correlation of the signals to behavior, the more our predictive machine learning will allow us to predict the signal that will result in that behavior,” he said. “This way we are detecting it before the behavior occurs.”
While more research on that is needed, Rezai believes it’s a very important area of treating addictive behavior.
“It’s simple sensors that you wear, so they’re not obstructive with your daily life, and they’re passively monitoring your body’s physiology,” he said. “Wearable sensor technology can be used to quantify and measure the physiology of the body linked to addiction.”
Patients for these studies at WVU’s Rockefeller Neurosciences Institute will largely be West Virginians afflicted and impacted by addiction conditions.
“We’ve got to help the population of West Virginia, but also Pennsylvania, Ohio, Kentucky and across the country. It’s a major effort, but our primary goal is to help the patients and the population of West Virginia with this new effort,” Rezai said. “Our goal is regional, not just local but regional and national as well because a lot of the technology that we’re going to develop here will have impacts on patients across the country, so it’s more of a global vision for the Neuroscience Institute here.”
November 24, 2017
It is a global fact that Parkinson's diseases often starts with a tremor in one hand; in fact, some patients show other symptoms like slow movement, stiffness as well as loss of balance. This shows that it is unlike any other disease and can erect difficulty for patients. This type of disorder is characterised by the some sort of disturbance in the nervous system that affects movement of patients. According to medical terms, it develops slowly and in fact, hidden and cannot be noticed. However, it must be noted that patients always feel a tremor, which is widespread sign of Parkinson's disease.
People in their earlier stages of Parkinson's disease
According to some medical reports, people in their earlier stages of Parkinson's disease only face consistent stiffness as well as tremors and often exhibit little or you say no expressions at all. Doctors often recognise such disease by recognising soft speech, which is quite difficult to spot. However, Parkinson's disease symptoms worsen as the condition progresses.
According to some experts, the frequency of tremors or shaking
According to some experts, the frequency of tremors or shaking is highly variable, which makes it quite difficult to detect in patients. And the symptoms vary from patient to patient. But fortunately, due to the advent of medical technology doctors are able to use a wide range of tremor evaluation techniques. Many experts use their own approaches and tricks to identify the issue.
Parkinson's disease can minimise the overall ability
Here, it must be noted that Parkinson's disease can minimise the overall ability of a person to move and slow the movement. It makes the task quite difficult as well as time-consuming. People also find it difficult to walk because of continuous shaking of legs and hands. Also, people often drag their feet during walking.
Since Parkinson's disease can't be cured
Since Parkinson's disease can't be cured, only certain types of medications may reportedly improve the signs and symptoms. In some cases, medical experts suggest surgery to manage certain areas of brain.
Symptoms of the disease
Seeing the overall symptoms of the disease, many doctors suggest certain lifestyle changes, such as aerobic exercise. In fact, some types of physical therapy are also recommended to manage the problem. Such therapies are quite significant. Today, doctors also suggest taking help of a speech-language pathologist in order to enhance speech related problems. Believe it or not, it helps patients to improve their lifestyle.
Parkinson's disease may disturb
As it is a well-established fact that Parkinson's disease may disturb the sense of balance, doctors recommend regular exercising because it can efficiently improve the overall muscle strength, as well as flexibility. In fact, it is significant to minimise anxiety in patients. So, don’t wait, just talk to your doctors regarding your problem...
MR. BIG's BILLY SHEEHAN Says PAT TORPEY Has 'Demonstrated Incredible Courage' During Battle With Parkinson's Disease
November 23, 2017
November 24, 2017
New research from the University of Aberdeen shows that weight loss in people with Parkinson's disease leads to decreased life expectancy, increased risk of dementia and more dependency on care.
The team, led by Dr Angus Macleod propose that closer monitoring for weight loss in Parkinson's patients and interventions in those who lose weight, such as a high calorie diet, may improve life expectancy, reduce dementia and reduce dependence on carers.
The study, published in Neurology, followed 275 people with Parkinson's disease and parkinsonian disorders for up to ten years, monitored patients' weight and investigated associations between weight loss and outcomes of the disease. The main findings showed that weight loss is common in Parkinson's disease and in the parkinsonian disorders and can occur in the early stages of the disease. Further analysis showed that this early weight loss is associated with higher risk of becoming dependent (i.e. needing help with activities of daily living), of developing dementia, and of dying.
Although other studies have identified weight loss as a common problem in Parkinson's disease, this is the first to identify the link between weight loss and death, dementia and dependence on carers.
Dr Angus MacLeod who led the study explained: "Weight loss is a common problem in Parkinson's but it wasn't clear before we did this how common it was, mainly because of biases in previous studies, or what the consequences were of weight loss. Our hypothesis was that people who are losing weight were going to have adverse outcomes.
"Our finding that those who lose weight have poorer outcomes is important because reversing weight loss may therefore improve outcomes. Therefore, it is vital that further research investigate whether e.g. high calorie diets will improve outcomes in people with Parkinson's who lose weight.
The study was partially funded by Parkinson's UK. Professor David Dexter, Deputy Director of Research at Parkinson's UK added: "While other studies have demonstrated that weight loss is common in Parkinson's, this is the first to consider the impact this symptom may have.
"It has yet to be determined whether this quicker progression can be corrected by supplementation with a high calorie diet, however this could be a key potential development."
Journal reference: Neurology
Provided by: University of Aberdeen