TRANSLATE

Welcome to Our Parkinson's Place


I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible. I have Parkinson's
diseases as well and thought it would be nice to have a place where
updated news is in one place. That is why I began this blog.
I am not responsible for it's contents, I am just a copier of information searched on the computer. Please understand the copies are just that, copies and at times, I am unable to enlarge the wording or keep it uniformed as I wish. This is for you to read and to always keep an open mind.
Please discuss this with your doctor, should you have any questions, or concerns. Never do anything without talking to your doctor. I do not make any money from this website. I volunteer my time to help all of us to be informed. Please No advertisers, and No Information about Herbal treatments. This is a free site for all.
Thank you.


Friday, November 24, 2017

Imaging Technique Shows Progress of Alzheimer’s at Cell Level and Below

NEUROSCIENCE NEWS  NOVEMBER 24, 2017
Source: University of Twente.


Summary: Using Raman imaging technology, University of Twente researchers have been able to obtain clear images of brain tissue affected by Alzheimer’s disease.


The high-lighted squares (left) are the 30 by 30 micron areas in the middle and right images (upper: plaque, lower: tangle) NeuroscienceNews.com image is credited to the researchers.


Using ‘Raman’ optical technology, scientists of the University of Twente, can now produce images of brain tissue that is affected by Alzheimer’s disease. The images also include the surrounding areas, already showing changes.

Alzheimer’s disease is associated with areas of high protein concentration in brain tissue: plaques and tangles. Raman imaging is now used to get sharp images of these affected areas. It is an attractive technique, because it shows more than the specific proteins involved. The presence of water and lipids, influenced by protein presence, can also be detected. Using this technique, the researchers have studied brain tissue of four brain donors, three of them with Alzheimer’s disease.

TRANSITION
The affected area can, in this way, be shown in a sharp and clear way. After image processing, even an area appears that is in transition between healthy and affected tissue: this may give an indication how the disease is spreading in the brain. Even in the brain tissue of the healthy person, a small area is detected with protein activity. This can be a first sign of a neurodegenerative disease.

Raman microscopy uses a laser beam for the detection of chemical substances. The energy of the reflected and scattered light gives an indication of the substances present in a sample. In each of the four brain samples, 4096 spectra were examined in this way. A major advantage of Raman is that the chemicals don’t need a pretreatment, it is ‘label free’. In chemical analysis, Raman has proven to be a powerful technique.

SMALLER THAN A CELL 
In this case, Raman was used to examine brain tissue outside the body, but it could even be used ‘in vivo’ for detecting specific areas during surgery. Compared to MRI, PET and CT imaging, Raman is able to detect areas, smaller than cells, with very high precision. In this way, it can be a very valuable extra technique. The Raman images now show protein activity at neural cell level, but the sensitivity is high enough for detecting areas that are even smaller – as is the case with the brain sample of the healthy person.
ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE
Cees Otto, of the Medical Cell Biophysics group of UT, published his work in Scientific Reports, together with colleagues from Leiden University and from Spain and Austria.
Source: Wiebe Van Der Veen – University of Twente
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to the researchers.
Original Research: Full open access research for “Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients” by Ralph Michael, Aufried Lenferink, Gijs F. J. M. Vrensen, Ellen Gelpi, Rafael I. Barraquer & Cees Otto in Scientific Reports. Published online November 15 2017 doi:10.1038/s41598-017-16002-3


Abstract

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
Neuritic plaques and neurofibrillary tangles are crucial morphological criteria for the definite diagnosis of Alzheimer’s disease. We evaluated 12 unstained frontal cortex and hippocampus samples from 3 brain donors with Alzheimer’s disease and 1 control with hyperspectral Raman microscopy on samples of 30 × 30 µm. Data matrices of 64 × 64 pixels were used to quantify different tissue components including proteins, lipids, water and beta-sheets for imaging at 0.47 µm spatial resolution. Hierarchical cluster analysis was performed to visualize regions with high Raman spectral similarities. The Raman images of proteins, lipids, water and beta-sheets matched with classical brain morphology. Protein content was 2.0 times, the beta-sheet content 5.6 times and Raman broad-band autofluorescence was 2.4 times higher inside the plaques and tangles than in the surrounding tissue. The lipid content was practically equal inside and outside. Broad-band autofluorescence showed some correlation with protein content and a better correlation with beta-sheet content. Hyperspectral Raman imaging combined with hierarchical cluster analysis allows for the identification of neuritic plaques and neurofibrillary tangles in unstained, label-free slices of human Alzheimer’s disease brain tissue. It permits simultaneous quantification and distinction of several tissue components such as proteins, lipids, water and beta-sheets.
“Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients” by Ralph Michael, Aufried Lenferink, Gijs F. J. M. Vrensen, Ellen Gelpi, Rafael I. Barraquer & Cees Otto in Scientific Reports. Published online November 15 2017 doi:10.1038/s41598-017-16002-3

http://neurosciencenews.com/cellular-imaging-alzheimers-8027/

Silver Linings: Sharon Desatnik

November 24, 2017 / BECKY RASPE | SPECIAL SECTIONS STAFF REPORTER 

Sharon volunteers at many organizations, like the Kids in Need Resource Center in Cleveland, where she helps send school supplies to school districts in need. 


When Sharon Desatnik was diagnosed with Parkinson’s disease in 2012, she suddenly found herself in need of care and didn’t have any choice but to retire from her job as a physical therapist at Menorah Park in Beachwood.
“This was after 30 years of being a caregiver, which I loved to do,” Desatnik said. “After the forced retirement, I was lost. Nothing I looked for suited me. And then one day, someone asked me to volunteer for a day at a Ronald McDonald House, and it was like a lightbulb went off. I used to volunteer a lot when I was younger, and that experience made me remember that I really loved volunteering.”
CJN: Where do you volunteer?
Desatnik: Because I am on disability, I am limited where I can volunteer. I started with the Ronald McDonald House, but now I volunteer at the Kids in Need Resource Center downtown, and it’s a program that supplies school supplies to districts that have over 65 percent of children on a subsidized lunch program.
Through my temple, I have done quite a bit. I work with my sisterhood. I also cook meals for the synagogue for people who are sitting Shiva, have had a baby or cannot cook. I also host at the temple. 
I also go to InMotion, which is a Parkinson’s wellness center. I go there as a client, but I also volunteer in the spin class, where I set up people on the bikes and teach them how to use them. I also make calls to people who have hit hard times and try to keep in touch with them there, too. I started helping people on the bikes because I know how to do it. I also do some coaching in the older classes. I deliver books to the Shaker (Heights) library, too. 
The point for me was that I was really lost when I retired, as I worked 55 hours a week. Volunteering has really become a ‘silver lining’ for me, it saved me. I went from a caregiver to needing care, and it inspired me to give back.
CJN: Why do you volunteer at the Kids in Need Resource Center?
Desatnik: I went to the Federation’s (Jewish Federation of Cleveland’s) volunteer morning and they had a volunteer open house with lots of different organizations. I wanted to find something to do because my walking is impaired. I wanted to find something I could do on a daily basis that is really enjoyable. There was really a wealth of things to do and (the Kids in Need Resource Center) just fell into my lap.
CJN: How did your diagnosis with Parkinson’s disease inspire you to volunteer within that community?
Desatnik: So many people help me and give me support – it has been a life-changing diagnosis. It ended my career and changed my relationship with my grandchild. But it has also given me the opportunity to give back. I was always caring for people and without helping others, I felt very diminished. I was lost and the first year of my diagnosis was just very hard. Volunteering in that community has really filled that need to help people. And in doing so, I help myself.
CJN: How has volunteering changed you and when did you start?
Desatnik: It’s the right thing to do and I have always done it. As I started working more and more, I was doing most of my giving back through work. Volunteering now just gives me an opportunity to start again.
My parents had us get involved in BBG (B’nai B’rith Girls) and our temple’s groups. When I came back to Cleveland from school, I didn’t know anyone. Volunteering has also helped me meet a number of friends, even now. It’s always been a push from my parents, and my mom was always involved in Jewish organizations and my dad would give blood. They wanted to give back in any way they could, and that just inspired me from a young age. 
Desatnik said as the years go on, she’d love to do as much as she can within her physical limitations. 
“I might start going to the resource  center more and I will continue to volunteer through my synagogue,” she said. “I need to give back, especially if I continue to accept more help. I am only a whole person when I give back.”
https://www.clevelandjewishnews.com/features/silver_linings/silver-linings-sharon-desatnik/article_3a56cda2-ce1a-11e7-a8c6-1f81f3cf11ab.html

New WVU Rockefeller Neurosciences Institute director brings plans for new research, clinical trials

By  in News | November 24, 2017







MORGANTOWN, W.Va. — WVU’s newest director of the Rockefeller Neurosciences Institute is bringing with him new tools and clinical trials to target the state’s opioid epidemic.
Dr. Ali Rezai outlined the newest advances in fighting neurological diseases, including opioid addiction, in a presentation during WVU’s third annual Academic Media Day on Nov. 13 — only 10 days after taking his position.
“There’s been tremendous advances in brain imaging and how we can visualize brain disorders,” Rezai said. “We’re able to understand the science of addiction even better than before.”
Prior to coming to WVU, Rezai served as director of Ohio State University’s Wexner Medical Center’s Neurological Institute, where he was involved in pioneering the use of brain pacemakers for treating Parkinson’s disease, depression, obsessive compulsive disorder and traumatic brain injury.
Now at WVU’s Rockefeller Neurosciences Institute, he hopes to continue that research to use the technology to treat addiction. Some of the developments could be rolling out as early as next year, unlike anything West Virginians have had access to before.
“There have been brain implants for alcohol in Europe, but we’re going to be starting a new study looking at brain implants for addiction,” Rezai said. “There’s a lot of work being done with external modulation with magnets and external electrical stimulations for addictions.”
Rezai said the goal would be to use ultrasound-based neuromodulation for addictions and develop a protocol for brain implant for severe addictions.
“Implants aren’t for the initial phase of addiction,” he said. “These are for patients who have had all the therapies done and have failed and are very disabled.”
In order to meet these goals, WVU will be partnering with many other institutions and companies to explore other technology, such as virtual reality technology, micropellet technology, magnetic stimulation and electrical stimulation technology.
“So we’ll become a rapid research and development kind of effort, so we can help patients very quickly,” Rezai said. “That’s our goal — having a very quick way of helping those afflicted with neurological conditions from chronic pain, to addictions, to Alzheimer’s, to autism, to stroke and many others.”
Micropellets, which are non-steroid, non-opioid medications, would be inserted into the body post-surgery as a pain relief to block addiction at the root before it even begins.
“First dose (of an opioid) you take, your brain changes, the chemistry of your brain changes, so this can lead to addictive behavior over time. Not everybody becomes addicted, but a certain example of the population can get addicted,” Rezai said. “So the goal is to not give the Oxycodone and narcotics or these addictive medications and instead give them local treatment, such as this micropellett that delivers the medication locally without the need to take a pill that gets systemically, that gets absorbed and goes to your brain and can make you more addicted.”
For addictions milder than those needing implants, research is also looking at external, wearable technology to track the sensors in the brain that cause addiction.
“When you’re craving or you’re seeking medications or drugs, the body’s physiology is off and is making you seek the drugs,” Rezai said. “The part of the brain that controls addictions, sends signals to the rest of the body in terms of anxiety, in terms of changes in blood vessels, in terms of changes of your heart rate varibility. There’s a number of elements or signals that go from the brain to the rest of the body.”
The goal, Rezai said, would be to detect those signals before a patient even takes the drug occurs and correlate those signals to the behavior.
“The more we can do the correlation of the signals to behavior, the more our predictive machine learning will allow us to predict the signal that will result in that behavior,” he said. “This way we are detecting it before the behavior occurs.”
While more research on that is needed, Rezai believes it’s a very important area of treating addictive behavior.
“It’s simple sensors that you wear, so they’re not obstructive with your daily life, and they’re passively monitoring your body’s physiology,” he said. “Wearable sensor technology can be used to quantify and measure the physiology of the body linked to addiction.”
Patients for these studies at WVU’s Rockefeller Neurosciences Institute will largely be West Virginians afflicted and impacted by addiction conditions.
“We’ve got to help the population of West Virginia, but also Pennsylvania, Ohio, Kentucky and across the country. It’s a major effort, but our primary goal is to help the patients and the population of West Virginia with this new effort,” Rezai said. “Our goal is regional, not just local but regional and national as well because a lot of the technology that we’re going to develop here will have impacts on patients across the country, so it’s more of a global vision for the Neuroscience Institute here.”
http://wvmetronews.com/2017/11/24/new-wvu-rockefeller-neurosciences-institute-director-brings-plans-for-new-research-clinical-trials/

Addressing the problem of Parkinson's diseases

November 24, 2017



It is a global fact that Parkinson's diseases often starts with a tremor in one hand; in fact, some patients show other symptoms like slow movement, stiffness as well as loss of balance. This shows that it is unlike any other disease and can erect difficulty for patients. This type of disorder is characterised by the some sort of disturbance in the nervous system that affects movement of patients. According to medical terms, it develops slowly and in fact, hidden and cannot be noticed. However, it must be noted that patients always feel a tremor, which is widespread sign of Parkinson's disease. 

People in their earlier stages of Parkinson's disease
According to some medical reports, people in their earlier stages of Parkinson's disease only face consistent stiffness as well as tremors and often exhibit little or you say no expressions at all. Doctors often recognise such disease by recognising soft speech, which is quite difficult to spot. However, Parkinson's disease symptoms worsen as the condition progresses. 

According to some experts, the frequency of tremors or shaking
According to some experts, the frequency of tremors or shaking is highly variable, which makes it quite difficult to detect in patients. And the symptoms vary from patient to patient. But fortunately, due to the advent of medical technology doctors are able to use a wide range of tremor evaluation techniques. Many experts use their own approaches and tricks to identify the issue. 

Parkinson's disease can minimise the overall ability
Here, it must be noted that Parkinson's disease can minimise the overall ability of a person to move and slow the movement. It makes the task quite difficult as well as time-consuming. People also find it difficult to walk because of continuous shaking of legs and hands. Also, people often drag their feet during walking

Since Parkinson's disease can't be cured
Since Parkinson's disease can't be cured, only certain types of medications may reportedly improve the signs and symptoms. In some cases, medical experts suggest surgery to manage certain areas of brain. 

Symptoms of the disease
Seeing the overall symptoms of the disease, many doctors suggest certain lifestyle changes, such as aerobic exercise. In fact, some types of physical therapy are also recommended to manage the problem. Such therapies are quite significant. Today, doctors also suggest taking help of a speech-language pathologist in order to enhance speech related problems. Believe it or not, it helps patients to improve their lifestyle. 

Parkinson's disease may disturb
As it is a well-established fact that Parkinson's disease may disturb the sense of balance, doctors recommend regular exercising because it can efficiently improve the overall muscle strength, as well as flexibility. In fact, it is significant to minimise anxiety in patients. So, don’t wait, just talk to your doctors regarding your problem...

http://www.selfgrowth.com/articles/addressing-the-problem-of-parkinsons-diseases

MR. BIG's BILLY SHEEHAN Says PAT TORPEY Has 'Demonstrated Incredible Courage' During Battle With Parkinson's Disease

November 23, 2017


Italy's Rock Rebel magazine recently conducted an interview with guitarist Paul Gilbert and bassist Billy Sheehan of MR. BIG. You can watch the entire chat below. A few excerpts follow (transcribed by BLABBERMOUTH.NET). 
On the difference between touring with MR. BIG versus their solo projects and side bands such as THE WINERY DOGS:
Paul: "MR. BIG, there's more people in the audience, which is nice. It's MR. BIG music; we all sing together, which is great. There's a lot of harmony vocals in addition to the bass and guitar wildness. And, for me, it pushes me to be more intense. There's sort of an energy level requirement that MR. BIG has that if I was just on my own getting out of bed in the morning at my house, I might not ever get to that energy during the day on my own. But with MR. BIG, it brings me up to a higher energy level than I ever would on my own. That's nice to be pushed and push myself that much." 
Billy: "Similarly, it's a pretty intense show. It seems sometimes it's just a regular rock or pop song, but we're doing a lot and singing a lot and all kinds of things are going on. MR. BIG has been, for all of us, our most successful band for all of us, all of us in the band. We've played all over the world as I already mentioned and it's incredible to play. We play in South America and they sing the guitar solos. They sing along with the guitar solos, so the fact that the fans are so familiar with what we do and they sing along, we're really locked together with the audience in a really incredible way, which means a lot to us. We have dear friends and wonderful people all over the world, no matter where we play, somebody's there and they got a record or a MR. BIG shirt, even if they got to make it themselves, they got a MR. BIG shirt. It's quite a wonderful thing. We both do a lot of things outside of MR. BIG, but I would dare to say that not necessarily to speak for PaulPat [Torpey, drums], Eric [Martin, vocals] or [fill-in drummer] Matt [Starr], but MR. BIG is a very special thing for all of us." 
On Torpey, who suffers from Parkinson's disease, joining MR. BIG on their current European tour and whether the band considers themselves "one big family": 
Billy: "You could say that, yeah, absolutely. Pat, unfortunately, ran into a bad situation and as a band, we wanted to make sure that he knew that we were with him 100 percent. It's a tough thing for everybody, but Pat has demonstrated incredible courage and strength. He's inspiring to so many people all over the world. I get e-mails from people every day who maybe don't have the same affliction, but have something similar and Pat inspires them to get out of bed and get going and push back a little bit more. I think that's a wonderful thing in itself. The American military, the Navy Seals and their motto is 'No Man Left Behind.' So for the beginning of this, we adopted their motto to a rock band and [it was] 'No Man Left Behind'. A lot of bands are out there now and they don't have all the original members. Sad, sometimes you can't. People pass on and situations, but we really want it to be PaulEric, myself and PatMatt is incredible at helping out. I have to mention how awesome he is and how wonderful a job he's done to do Pat's parts the way they should be done. Really wonderful." 
On whether MR. BIG ever writes material they know they wouldn't be able to replicate live:
Billy: "I think everything we do is designed to be performed live. I think that's where some bands get into trouble. They get into the studio to do all of this fancy stuff, but they can't do it live. So they get live and it's not that good. I've seen that happen with several very famous bands, too. When we designed this band way back when we first began rehearsing at Alleyway Studios and when we were in there rehearsing and we were just playing live and when we put this band together, we kept 'live' in mind completely. When I heard Eric sing, I thought, 'That guy's got a great voice.' I heard some live things of him, he's amazing. Paul, of course, I had seen him for several years before we started MR. BIG and he just killed live. Pat Torpey, I saw him perform live, just great. I really wanted to build the band as a live band so it would be 'real.' A lot of bands, they faked a lot of stuff. They can do it in the studio, they can't really do it quite live. We really wanted to make that connection true and honest. I think it makes a big difference to the fans. Sometimes when we sing, we break in the middle of 'Green-Tinted [Sixties Mind]', we just sing the middle harmony part with no music. 'Is that recorded?' Sometimes we go live, 'There aren't any tracks playing!' It's not fake. We keep that in mind. Then, it's a challenge when we do something that's difficult, we got to perform it live. We have to figure out a way to do it. It's a good challenge." 
MR. BIG's ninth studio album, "Defying Gravity", was released on July 7 via Frontiers Music Srl. The effort is available at traditional retail and all digital service providers, as is a deluxe-edition version with CD and bonus DVD that features music videos and a behind-the-scenes look at the making of the album.

https://youtu.be/eGW3pdJ_ra0


https://youtu.be/elkYpuUeB3w


https://youtu.be/2C0hRtNTsfk


http://www.blabbermouth.net/news/mr-bigs-billy-sheehan-says-pat-torpey-has-demonstrated-incredible-courage-and-strength-during-battle-with-parkinsons-disease/

Changes in diet may improve life expectancy in Parkinson's patients

November 24, 2017



New research from the University of Aberdeen shows that weight loss in people with Parkinson's disease leads to decreased life expectancy, increased risk of dementia and more dependency on care.

The team, led by Dr Angus Macleod propose that closer monitoring for  in Parkinson's patients and interventions in those who lose , such as a high calorie diet, may improve , reduce  and reduce dependence on carers.
The study, published in Neurology, followed 275 people with Parkinson's disease and parkinsonian disorders for up to ten years, monitored patients' weight and investigated associations between weight loss and outcomes of the disease.   The main findings showed that weight loss is common in Parkinson's disease and in the parkinsonian disorders and can occur in the early stages of the disease.  Further analysis showed that this early weight loss is associated with higher risk of becoming dependent (i.e. needing help with activities of daily living), of developing dementia, and of dying.
Although other studies have identified weight loss as a common problem in Parkinson's disease, this is the first to identify the link between weight loss and death, dementia and dependence on carers.
Dr Angus MacLeod who led the study explained: "Weight loss is a common problem in Parkinson's but it wasn't clear before we did this how common it was, mainly because of biases in previous studies, or what the consequences were of weight loss. Our hypothesis was that people who are losing weight were going to have adverse outcomes. 
"Our finding that those who lose weight have poorer outcomes is important because reversing weight loss may therefore improve outcomes. Therefore, it is vital that further research investigate whether e.g. high calorie diets will improve outcomes in people with Parkinson's who lose weight.
The study was partially funded by Parkinson's UK. Professor David Dexter, Deputy Director of Research at Parkinson's UK added: "While other studies have demonstrated that weight loss is common in Parkinson's, this is the first to consider the impact this symptom may have.
"It has yet to be determined whether this quicker progression can be corrected by supplementation with a , however this could be a key potential development."
Journal reference: Neurology
Provided by: University of Aberdeen
https://medicalxpress.com/news/2017-11-diet-life-parkinson-patients.html

Thursday, November 23, 2017

LIGHT OF DAY WINTERFEST 2018 Tickets On Sale Saturday

By BWW News Desk - Nov. 22, 2017 



With a goal of topping last year's record-breaking $550,000 raised in its ongoing battle against Parkinson's disease, LIGHT OF DAY WINTERFEST 2018, presented by the Asbury Park Press, the 18th anniversary edition of the anchor event for the world-renowned Light of Day Foundation, will bring over 150 music acts to 30 venues over 10 days in two New Jersey cities, New York City, and Philadelphia, in January, following a holiday season European tour.
Tickets go on sale Saturday, Nov. 25 at NOON EST for the Asbury Park portion of LIGHT OF DAY WINTERFEST 2018, where the bulk of the action will occur, being held Jan. 5-15, 2018 at such fabled rock venues as the Paramount Theater, the Stone Pony, the Saint, the Wonder Bar, House of Independents and the Asbury Hotel, among others. Tickets are available through Ticketmaster (www.ticketmaster.com), Ticketmaster charge-by-phone at 1-800-745-3000, and all Ticketmaster outlets. A wide variety of combination ticket packages - as well as single tickets to each show - will be available.
Albert Lee and Band, Greg Kihn, Joe Grushecky and The Houserockers, Willie Nile and Band, Garland Jeffreys, James Maddock and Band, Joe D'Urso and Stone Caravan, Billy Hector Band, Kashmir: The Live Led Zeppelin Show, Bobby Bandiera and his popular Tom Petty tribute, Jeffrey Gaines, Christine Martucci, Bruce Tunkel, the Slyders, Sandy Mack Allstars, Kyle Ward, Billy Hector Band, Colossal Street Jam, Tara Tote, and the Billy Walton Band are among the first wave of acts to be announced for LIGHT OF DAY 2018. More acts will be announced as the festival approaches.
Concert goers can purchase tickets for individual shows, on an a la carte basis, including BOB'S BIRTHDAY BASH, at the Paramount Theater, scheduled for Jan. 13, 2018. Tickets for Bob's Birthday Bash range from $43 to $209.50, and tickets for the other club shows range from Free to $35. Concert goers can purchase a LIGHT OF DAY COMBO TICKET PACKAGE to gain admission to all Asbury Park events (Approximately 50 EVENTS) at five different levels, starting at $159.50. The packages GUARANTEE a reserved seat for BOB'S BIRTHDAY BASH at the Paramount Theatre, along with admission to all shows, capacity permitting, first-come, first-served basis. Ticket prices DO NOT include any fees and/or service/convenience charges.
The complete festival schedule and array of ticket packages are below:
Ticket packages include (all seat descriptions are approximate):
Platinum "All Access" Combo package: $325 - "very best" orchestra seats, including pit seats and first 10 rows at the Paramount. The ticket package also includes a commemorative Light of Day New Jersey 2018 VIP laminate; a Light of Day New Jersey 2018 T-shirt, and a L'Oreal gift bag worth more than $200, plus admission to all other Light of Day Asbury Park 2018 events.
Platinum "Bob's Birthday Bash" Paramount Only Ticket: $209.50 - same as Platinum "All Access" Combo package except it DOES NOT INCLUDE admission to all other Light of Day Asbury Park 2018 events.
Gold combo package: $249.50 - includes great front and mid-orchestra in rows 11 to 16 and the loge, and closer seats on the left and right sides at the Paramount. The ticket package also includes a commemorative Light of Day 2018 laminate, plus admission to all Light of Day Asbury Park 2018 events.
Gold "Bob's Birthday Bash" Paramount Only Ticket: $159.50 - same as Gold "All Access" Combo package except it DOES NOT INCLUDE admission to all other Light of Day Asbury Park 2018 events.
Silver combo package: $199.50 - includes great mid- and rear orchestra and lower side orchestra seats at the Paramount. The ticket package also includes admission to all Light of Day Asbury Park 2018 events. 
Silver "Bob's Birthday Bash" Paramount Only Ticket: $119.50 - same as Silver "All Access" Combo package except it DOES NOT INCLUDE admission to all other Light of Day Asbury Park 2018 events.
Bronze combo package: $159.50 - includes rear orchestra and balcony seats at the Paramount, plus admission to all other Light of Day Asbury Park 2018 events. The best seats for the dollar!
Bronze "Bob's Birthday Bash" Paramount Only Ticket: $89.50 - same as Silver "All Access" Combo package except it DOES NOT INCLUDE admission to all other Light of Day Asbury Park 2018 events.
Super Savers - $53 and $43 - Rear upper balcony seating for "Bob's Birthday Bash" only. 
***Ticket prices do not reflect Ticketmaster and venue service/facility/convenience charges.
****Please note: All combo tickets guarantee your seat at the Main Event. However, admission to all other Light of Day Asbury Park events is subject to capacity restrictions at their respective venue.
Individual event ticket prices:
Friday, JAN 5
LOD "NORTH JERSEY" Outpost in the Burbs, Montclair, NJ, 7pm, $TBA
Saturday, JAN 6
LOD "Philadelphia," The World Cafe, Upstairs, Philadelphia, Pa., 7pm, $TBA
Sunday, JAN 7
LOD "COVER ME: BEST OF THE JERSEY BAR BANDS", Stone Pony, All Ages, 1pm, $TBA
Monday, JAN 8
LOD "HAPPY MONDAYS", Wonder Bar, Mon., 21+, $TBA
Wednesday, JAN 10
LOD "NYC", The Cutting Room, 18+, 7pm, $75 VIP Reserved Seating, $45 GA Reserved Seating, $25 GA Standing
Thursday, JAN 11
LOD "FIRST NOTE", The Saint, Thurs.,18+, 6:30pm, $8adv/$12dos
LOD "SANDY MACK's WONDER JAM", Wonder Bar, Thurs.,21+, 7pm, $12
LOD "WINTERFEST 2018 KICK-OFF", House Of Independents, Thurs.,18+, 7pm, $20adv/$25dos
LOD "MONMOUTH UNIVERSITY'S BLUE HAWK RECORDS PRESENTS", Langosta Lounge, Thurs., All-Ages, 7pm, FREE ADMISSION
Friday, JAN 12
LOD "ASBURY ANGELS INDUCTION", Stone Pony, Fri., All Ages, 6:30pm, $25adv/$30dos
LOD TBA, House Of Independents, Fri.,18+, 7pm, $TBA
LOD "ROCK HEAVY", The Saint, Fri.,18+, 8pm, $8adv/$12dos
LOD "OPEN MIC", Wonder Bar, Fri., 21+, 6pm, $12
LOD TBA, McLoone's Supper Club, Fri., All Ages, Doors/Dinner 6pm/ Show 8pm, $TBA
LOD "LATE NIGHT FRIDAY" Langosta Lounge, l, Friday, 21+, 9pm, FREE ADMISSION
LOD "TBA" Paramount Theater, Fri., All Ages, 8pm, $TBA
Saturday, JAN 13
LOD "BOB'S BIRTHDAY BASH", Paramount Theater, Sat, All Ages, 6pm, $43-$205
LOD "ROCK", The Saint, Sat., 18+, 7:30pm, $8adv/ $12dos
LOD TBA, McLoone's Supper Club, Sat., All Ages, Noon, $TBA
LOD TBA, McLoone's Supper Club, Sat., 18+, 7pm, $TBA
LOD "LATE NIGHT SATURDAY", Langosta Lounge, Sat., Jan. 17, 21+, 10pm, FREE ADMISSION
LOD "TBA", House Of Independents, Sat., 18+, 8pm, $TBA
LOD "ASBURY BLUES", Wonder Bar, Sat., All Ages, Noon, $12/$15
LOD "FULL TILT BOOGIE BASH", Wonder Bar, Sat., 21+, 7pm, $12/$15
LOD "DOWNTOWN - ASBURY UNDERGROUND," curated by Pat Schiavino and Asbury Underground. Noon - 7PM Over 20 venues! FREE ADMISSION
Sunday, JAN 14
LOD "SONGWRITERS BY THE SEA BOARDWALK CRAWL", Watermark, Sun., All Ages, Noon, $15
LOD "SONGWRITERS BY THE SEA BOARDWALK CRAWL", Langosta Lounge, Sun., All Ages, 3pm, $15
LOD "SONGWRITERS BY THE SEA BOARDWALK CRAWL", McLoone's Supper Club, Sun., All Ages, 6pm, $20
LOD "KID'S ROCK", Stone Pony, Sun., All Ages, Noon, $15
LOD "MUSICIANS ON A MISSION", The Saint, Sun., 18+, Noon, $10
LOD "LAST NOTE", The Saint, Sun., 18+, 7:30pm, $8adv/$12dos
Monday, JAN 15
LOD "GOODBYE BRUNCH," Toast, Mon., All Ages, 10:30a-1:30p.
Light of Day WinterFest has gained international notoriety for surprise performances by Bruce Springsteen in 11 of the previous 17 years. In his recent autobiography, Born to Run, which topped the New York Times Best Sellers List as well as in several countries worldwide, Springsteen revealed that his father suffered from Parkinson's Disease.
Last year's event raised $555,000 - a record amount - to combat Parkinson's disease, topping the previous year's record of $525,000, with the 17-year total approaching $4.5 million.
Aside from Springsteen, previous LIGHT OF DAY WINTERFEST performers have included Michael J. FoxJohn Rzeznik (Goo Goo Dolls), Darlene LoveEd Kowalczyk (Live), Jakob Dylan, Suzanne VegaMax Weinberg (E Street Band), Jake Clemons (E Street Band), Lucinda Williams, Mike Peters (The Alarm, Big Country), David Bryan of Bon Jovi, David Bromberg, Alejandro Escovedo, Pete Yorn, The Smithereens, Peter Asher, Chuck Prophet, Joey Molland (Badfinger), Peter Himmelman, Gary U.S. Bonds, Southside Johnny, LaBamba's Big Band, John EddieMichael J. Fox starred with Joan Jett in the 1987 film titled after the Springsteen song (and live concert favorite) of the same name, which Fox and Jett sang in the movie.
LIGHT OF DAY WINTERFEST 2018 also will include shows in New York City (Jan. 10 @ The Cutting Room), North Jersey (Jan. 5 in Montclair), and Philadelphia (Jan. 6, @ World Café Live). They are the culmination of a worldwide series of shows that began as a one-day event in Asbury Park and grew in the U.S. to a 10-day festival in the New Jersey/New York/Philadelphia metropolitan area.
On the radio side, longtime LOD concert host Tom Cunningham will host his Sunday morning "Bruce Brunch" program on 105.7 "The Hawk," live from the Anchor's Bend restaurant, in the Convention Hall/Paramount Theatre complex, with very special guests, on Jan. 15, starting at 9 a.m.
These are heady times indeed for the Light of Day Foundation. In October, Gold's Gym in Howell, NJ, became the second location for BOXING FOR BOB Classes, FREE to Parkinson's disease patients, with participation fully funded by the Light of Day Foundation. The full-body, non-contact boxing therapy workout ? which also utilizes strength training, flexibility and balance drills - continues at its original location, Gladiator's Gym in Forked River, NJ, as well. Combined, the two locations are serving over 100 Parkinson's patients with thrice weekly instruction.
In 2016, the Foundation was able to proudly establish a $150,000 grant to the Parkinsons Disease Foundation, as well as host an incredibly successful matching grant drive with Cure PSP which raised an additional $200,000. CurePSP is the foremost organization working toward curing and preventing Parkinson's related diseases such as CBD and PSP.
More significantly, Light of Day has expanded into an internationally recognized tour, through a true grassroots effort of musicians, music fans and benefactors. Light of Day shows now take place around the world on three continents, this year including the 11th annual European tour - a 16-day holiday run in 9 countries (Nov. 24-Dec. 11). And for the fourth consecutive year, a Light of Day event was held over the summer in Australia. The two-day festival always takes place in the Australian city of Ocean Grove, Victoria, a sister city to Asbury Park neighbor Ocean Grove, NJ. Portions of proceeds from all shows are donated to local Parkinson's organizations.

Light of Day also fields a team in the annual Parkinson's Unity Walk in New York's Central Park. Over the years the Light of Day team has raised over $275,000.
ABOUT THE LIGHT OF DAY FOUNDATION
The Light of Day Foundation, Inc., utilizes the awesome power of music to raise money and awareness in its continuing battle to defeat Parkinson's disease and related neuro-degenerative diseases, specifically Progressive Supranuclear Palsy (PSP) and Amyotrophic Lateral Sclerosis (ALS), within our lifetime. The Foundation's mission is to fund research into possible cures, improved treatments and support for patients who suffer from those diseases, their families and their caregivers to help improve their quality of life. Gifts to the Light of Day Foundation, Inc. are tax-deductible to the full extent of the Internal Revenue Code. The Light of Day Foundation, Inc. is designated by the IRS as a not-for-profit 501(c) (3) organization. The Light of Day Foundation, Inc.'s Federal ID # is 20-1560386. Light of Day - the concerts and the organization - grew from a birthday party and fund-raiser held in 1998 at the Downtown Cafe in Red Bank to celebrate the 40th birthday of artist manager and music industry veteran Bob Benjamin, who was diagnosed with Parkinson's disease in 1996.
https://www.broadwayworld.com/new-jersey/article/LIGHT-OF-DAY-WINTERFEST-2018-Tickets-On-Sale-Saturday-20171122
SaveSave