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I have Parkinson's diseases and thought it would be nice to have a place where the contents of updated news is found in one place. That is why I began this blog.
I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible.
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Saturday, November 19, 2016
|This computer rendering shows the skeletonized structure of heterochromatin (red represents a thin region while white represents a thick region), a tightly packed form of DNA, surrounding another form of DNA-carrying material known as euchromatin (dark blue represents a thin region and yellow represent the thickest) in a mouse’s mature nerve cell. NeuroscienceNews.com image is credited to Berkeley Lab, UCSF.|
Source: Glenn Roberts Jr – DOE/Lawrence Berkeley National Laboratory
Image Source: NeuroscienceNews.com image is credited to Berkeley Lab, UCSF.
Video Source: The video is credited to Berkeley Lab.
•Soft X-ray tomography reveals chromatin networks in olfactory neurons
•Chromatin compaction increases during olfactory neurogenesis
•Condensed chromatin moves to nuclear core during differentiation
•HP1β regulates reorganization of chromatin in mature neurons
The realization that nuclear distribution of DNA, RNA, and proteins differs between cell types and developmental stages suggests that nuclear organization serves regulatory functions. Understanding the logic of nuclear architecture and how it contributes to differentiation and cell fate commitment remains challenging. Here, we use soft X-ray tomography (SXT) to image chromatin organization, distribution, and biophysical properties during neurogenesis in vivo. Our analyses reveal that chromatin with similar biophysical properties forms an elaborate connected network throughout the entire nucleus. Although this interconnectivity is present in every developmental stage, differentiation proceeds with concomitant increase in chromatin compaction and re-distribution of condensed chromatin toward the nuclear core. HP1β, but not nucleosome spacing or phasing, regulates chromatin rearrangements because it governs both the compaction of chromatin and its interactions with the nuclear envelope. Our experiments introduce SXT as a powerful imaging technology for nuclear architecture.
Friday, November 18, 2016
News from the American Neurological Association Annual Meeting: Deep Brain Stimulation Results Encouraging After Five Years of Follow up, Study Finds
|Dr. Mallory Hacker|
|Dr. Charles Adler|