I Ask This Of You!
I have Parkinson's diseases and thought it would be nice to have a place where the contents of updated news is found in one place. That is why I began this blog.
I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible.
I am not responsible for it's contents. I am just a copier of information searched on the computer. Please understand the copies are just that, copies and at times, I am unable to enlarge the wording or keep it uniformed as I wish.
This is for you to read and to always keep an open mind.
Please discuss this with your doctor, should you have any questions, or concerns.
Never do anything without talking to your doctor. I do not make any money from this website. I volunteer my time to help all of us to be informed. I will not accept any information about Herbal treatments curing Parkinson's, dementia and etc. It will go into Spam.
This is a free site for all with no advertisements.
Thank you for visiting!
Saturday, August 15, 2015
Addex Dipraglurant Demonstrates Anxiolytic- and Antidepressant-like Activity in Multiple Preclinical Models Relevant for Non-Motor Symptoms in Parkinson's Disease
Read more at: http://www.pharmatimes.com/Article/15-08-14/Roche_tests_Parkinson_s_app_dismantles_Heidelberg_deal.aspx#ixzz3iu1Vx7j0
Follow us: @PharmaTimes on Twitter
Thursday, August 13, 2015
Wednesday, August 12, 2015
Transdermal rotigotine, which is marketed as Neupro, is a dopamine receptor agonist that is used in the treatment of Parkinson's Disease. It offers the potential for continuous dopaminergic stimulation that could avoid the fluctuations observed with traditional forms of dopamine agonists. Neupro provides continuous delivery for 24 hours following application of the patch to intact skin. For more information go to : https://www.neupro.com/ and http://www.rxlist.com/neupro-drug.htm
Rotigotine made hardly any difference to the Non-motor symptom score in Parkinson's Disease. However, improvements were detected in mood and apathy. General symptom improvements and the PDQ-39 scores also favoured rotigotine. Transdermal rotigotine also improved swallowing. There was a significantly greater reduction in the off-time when using rotigotine. Adverse events reported more frequently with rotigotine were nausea, application site reactions, somnolence and headache. Serious adverse events were only uncommonly reported.
References : European Journal of Neurology  Jun 22 [Epub ahead of print] (A.Antonini, L.Bauer, E.Dohin, W.H.Oertel, O.Rascol, H.Reichmann, M.Schmid, P.Singh, E.Tolosa, K.R.Chaudhuri) http://www.ncbi.nlm.nih.gov/pubmed/26095948; Dysphagia  May 13 [Epub ahead of print] (M.Hirano, C.Isono, H.Sakamoto, S.Ueno, S.Kusunoki, Y.Nakamura) http://www.ncbi.nlm.nih.gov/pubmed/25966655; Journal of Neurology  261 (10) : 1887-1893 (M.Nomoto, Y.Mizuno, T.Kondo, K.Hasegawa, M. Murata, M. Takeuchi, J.Ikeda, T.Tomida, N.Hattori)
Tuesday, August 11, 2015
Researchers searched 'translatome' as opposed to genome
Discovery explains why one group of dopamine cells is more affected
- Researchers testing if daily chocolate supplements can help
- Cocoa contains phenylethylamine, shown to increase release of dopamine
- May reduce symptoms of Parkinson's disease
Monday, August 10, 2015
What do tandem bicycles, exoskeletons and ARM processors have in common? They're all helping in the fight against Parkinson's.
A bicycle made for two
The discovery came during a roadtrip across Iowa. Dr Jay Alberts was working in the Biomedical Engineering Department at the Cleveland Clinic, Ohio, when he volunteered to take a friend with Parkinson's on a week-long tandem ride across the American heartland. His motivation was simple: to demonstrate how an active lifestyle could, and should, be maintained after diagnosis.
To prepare, his friend trained for the trip on an exercise bike, pedalling at a steady rate of 60rpm. However, the trip provided her with an unexpected challenge: the tandem's shared drive chain forced her to pedal roughly 40% faster in order to match Alberts' swifter 85 rpm. Just two days into the trip, they were both surprised to notice that her symptoms had improved.
Significantly, the improvements were evident in the upper body, not just in the muscles that had done the pedalling. This was evidence that the assisted exercise had led to beneficial changes in the brain.
A spin class - with a robotic twist
"Sensors in the electro-mechanical legs detect the how hard the wearer is pushing on the pedals, and automatically adjust how much assistance to give."
It's not about the bike
Building a powered machine that interacts intimately with the movement of a human being isn't easy. The motorised limbs have to accurately track and mimic the kinematics of the hip, knee and ankle joints, so sensitive control mechanisms must be in place. After all, nobody will want to wear the device if it could manipulate their legs in an unsafe way.
"The exoskeleton has sensors to measure the loads, angles and pitch at each joint, and to constantly monitor the pressure bearing down on each pedal."
Read more: http://www.alphr.com/life-culture/1001327/shut-up-legs-fighting-parkinsons-with-cycling-and-robotics#ixzz3iSCUAJqm