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TRANSLATE

Thursday, August 29, 2013

PRAMIPEXOLE : EXTENDED RELEASE v IMMEDIATE RELEASE

29th July 2013 - New research

Research [2013] Jul 24
[Epub ahead of print] (M.Takanashi, Y.Shimo, T.Hatano, G.Oyama, N.Hattori)

Changing from Immediate release Pramipexole to Extended release Pramipexole was found to cause a reduction in Parkinson's Disease symptoms. Pramipexole, which is marketed as  Mirapex, Mirapexin, and Sifrol, is a dopamine agonist used in the treatment of Parkinson's Disease. For more information go to Mirapex and Mirapex ER.

This study aimed to evaluate the efficacy and safety of an extended-release tablet formulation of pramipexole (PPX-ER) given once daily when switched from an immediate-release tablet formulation (PPX-IR) given 3 times daily. The extended release version evens out the effect of Pramipexole. Parkinson's Disease symptom scores were reduced after 4 weeks and after 8 weeks. There was no change in the nocturnal and early morning symptoms (NEMS) score, or the Parkinson's Disease Sleep Scale (PDSS-2). Nearly two thirds of patients and caregivers preferred the extended release version.
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