28th March 2014 - New research
JAMA Neurology [2014] Mar 24 [Epub ahead of print] (M.F.Beal, D.Oakes, I.Shoulson, C.
Henchcliffe, W.R.Galpern, et al)
Coenzyme Q10, an antioxidant that has been widely used for Parkinson's Disease has been
JAMA Neurology [2014] Mar 24 [Epub ahead of print] (M.F.Beal, D.Oakes, I.Shoulson, C.
Henchcliffe, W.R.Galpern, et al)
Coenzyme Q10, an antioxidant that has been widely used for Parkinson's Disease has been
found to have no significant effect. Coenzyme Q10 (CoQ10) is a supplement, which supports
mitochondrial function in the neurons, and has been claimed to slow the progression of
Parkinson's Disease. For more information go to MedlinePlus :
http://www.nlm.nih.gov/medlineplus/druginfo/natural/938.html
People with Parkinson's Disease were given either a placebo, 1200mg of
CoQ10 per day, or 2400mg of CoQ10 per day. All of them were also
given 1200 IU per day of vitamin E. Participants were observed for 16
months or until a disability requiring dopaminergic treatment. The
treatments were well tolerated with no safety concerns. However, the
worsening of Parkinson's Disease was actually related to the higher
Coenzyme Q10 dose. Those taking no Coenzyme Q10 worsened by 6.9
points on the UPDRS. Those taking 1200mg worsened by 7.5 points.
Those taking 2400mg worsened by 8.0 points. So Coenzyme Q10 was not
only not beneficial it appeared, if anything, to be detrimental.
In previous studies Coenzyme Q10 was found to be ineffective in Parkinson's Disease in
daily doses of 200mg, 300mg, 400mg, 600mg, and 800mg. Only one Coenzyme Q10 study
has ever shown any improvement in Parkinson's Disease, using 360mg, but the effects were
mild and were only assessed for four weeks. Daily doses of 300mg, 600mg and 1200 failed to improve the symptoms of Parkinson's Disease but reduced the rate of deterioration.
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