PUBLIC RELEASE:
Parkinson disease (PD) appeared associated with 16 types of cancer in a study in Taiwan, an effort to explain the association in an East Asian population because most prior research has been conducted in Western populations, according to an article published online by JAMA Oncology.
During the past 50 years, more than 25 epidemiological studies have been conducted on the association between PD and cancer, and most of those studies showed that individuals with PD had a decreased risk of cancer compared to those without PD. However, most of those studies were done in Western populations and it has become clearer that genetic backgrounds play an important role in disease development.
Pan-Chyr Yang, M.D., Ph.D., of the National Taiwan University College of Medicine, Taipei, and coauthors used the Taiwan National Health Insurance Research Database to build a final study group of 62,023 patients newly diagnosed with PD from 2004 through 2010 and 124,046 control participants without PD.
The authors found a PD diagnosis was not associated with increased risk of breast, ovarian or thyroid cancers. However, PD appeared associated (as measured by increased hazard ratios) with 16 other cancers including malignant brain tumors, gastrointestinal tracts cancers, lung cancers, some hormone-related cancers, urinary tract cancers, lymphoma/leukemia, melanoma and other skin cancers.
The authors note limitations in their research, including possible underestimation of PD incidence, smoking status not included in their analysis, speculation about pesticide exposure, and remaining questions regarding genetic correlations.
"Based on this nationwide study on the association between PD [Parkinson disease] and cancer risk, we conclude that PD is a risk factor for most cancer in Taiwan. In our cohort, only breast, ovarian and thyroid cancers show no association with PD. Further studies are needed to clarify whether our findings can be applied to other East Asian populations. The striking differences between our study and the previous studies in Western cohorts suggest the importance of ethnicity and environmental exposures in disease pathogenesis," the article concludes.
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(JAMA Oncol. Published online June 18, 2015. doi:10.1001/jamaoncol.2015.1752. Available pre-embargo to the media at http://media.
Editor's Note: This study was supported by grants from the National Science Council and from Taichung Veterans General Hospital, Taiwan. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Media Advisory: To contact corresponding author Pan-Chyr Yang, M.D., Ph.D., email pcyang@ntu.edu.tw
To place an electronic embedded link in your story: Links will be live at the embargo time: http://oncology.
http://health.einnews.com/article/271516099/-5LBHne8uL5VVEAj
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| Parkinson's Linked to Various Cancers in East Asians |
Previous
studies on Parkinson's disease reveals that the neurodegenerative disorder
decreases the risk of cancer. However, new research on East Asian populations
reveal the opposite.
Taiwanese
scientists recently linked Parkinson's disease to 16 types of cancer.
Researchers noted previous studies on Parkinson's focused mostly on western
populations, and recent work reveals that genes play a significant role in an
individual's disease risk. The latest study involved data from Taiwan National
Health Insurance. Researchers compared 62,023 patients diagnosed with
Parkinson's disease from 2004 through 2010 to 124,046 control participants
without the neurodegenerative disorder.
The
latest findings linked Parkinson's disease to 16 other cancers including
malignant brain tumors, gastrointestinal tracts cancers, lung cancers, some
hormone-related cancers, urinary tract cancers, lymphoma/leukemia, melanoma and
other skin cancers.
However,
researchers were unable to link the disease to higher rates of breast, ovarian
or thyroid cancers.
"Based
on this nationwide study on the association between PD [Parkinson disease] and
cancer risk, we conclude that PD is a risk factor for most cancer in Taiwan. In
our cohort, only breast, ovarian and thyroid cancers show no association with
PD. Further studies are needed to clarify whether our findings can be applied
to other East Asian populations. The striking differences between our study and
the previous studies in Western cohorts suggest the importance of ethnicity and
environmental exposures in disease pathogenesis," lead researcher Pan-Chyr
Yang, M.D., Ph.D., of the National Taiwan University College of Medicine,
Taipei, and coauthors, wrote in the study.
http://health.einnews.com/article/271591380/0i4c3dnggIolGGBZ
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