10th September 2015 - New research
Although it normally has completely different uses, including orthostatic hypotension, the
prodrug droxidopa has been found to reduce the symptoms of Parkinson's Disease.
Droxidopa is a synthetic amino acid precursor. It can pass the blood brain barrier and form
noradrenaline and adrenaline, which are derivatives of L-dopa and dopamine. Droxidopa is
marketed as Northera.
For more information go to : http://www.rxlist.com/northera-drug.htm
The use of droxidopa in Parkinson's Disease was compared to
the use of a placebo. The two groups were comparable in all
respects. After two weeks and also nearly two months
Parkinson's Disease symptoms scores were significantly
different from the outset. Individual motor symptoms such as
stiffness, resting tremor, and alternate hand motion were also
significantly improved with the use of droxidopa, suggesting
that droxidopa is effective in improving rigidity, tremor and
alternate motion of hand.
Droxidopa was effective as symptomatic adjunct therapy, and significantly improved motor
function and activities of daily living. On the way to forming noradrenaline and adrenaline, it
must therefore have dopaminergic activity.
Reference : Parkinsonism and Related Disorders [2015] Aug 21 [Epub ahead of print] (S.
Zhao, R.Cheng, J.Zheng, Q.Li, J.Wang, W.Fan, L.Zhang, Y.Zhang, H.Li, S.Liu)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/26342560
http://www.viartis.net/parkinsons.disease/news/150910.pdf
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©2015 Viartis
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