WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Thursday, September 3, 2015

Scientists identify mechanism behind statin-induced muscle weakness

Sept. 2, 2015

New research suggests that muscle weakness and related side effects that can arise from statin use is likely due to the drug's effect on the energy production centers, or mitochondria, of muscle cells.
The researchers, from Radboud University Nijmegen Medical Center in the Netherlands, report their findings in the journal Cell Metabolism.
Statins are a commonly prescribed medication for lowering cholesterol; they work by blocking cholesterol production in the liver. Cholesterol is a major risk factor for heart disease and stroke, which cause nearly 1 in 3 deaths among Americans.
According to the Centers for Disease Control and Prevention (CDC), more than a quarter of American adults aged 40 and over use a prescription cholesterol-lowering medication, the vast majority of these being statins.
However, for around 25% of patients, statins can give rise to unpleasant side effects in the form of muscle weakness, pain and cramps, without any sign of damage to the tissue. These side effects can impair quality of life and often cause patients to stop taking the drugs.
Frans Russel, co-senior author of the new study and professor in molecular pharmacology and toxicology, says previous studies have linked side effects of statins and other drugs to mitochondria, but the underlying mechanisms are often unknown.

Lactone form of statin interferes with mitochondrial function

In the human body, statins exist in two forms: acid and lactone. Most statin drugs are of the acid form and target cholesterol production in the liver. The lactone form has no therapeutic effect - however, the acid form can convert to this type.
This would not normally be a problem except that the study shows the lactone form can interfere with the function of mitochondria - the powerhouses inside cells that produce ATP, the cellular "currency" of energy.
Using muscle cells from mice, the team showed that statins of the lactone form are around three times more powerful at disrupting mitochondria than those of the acid form.
They confirmed this finding in cells taken from muscle biopsies of patients experiencing statin-induced side effects.
They showed that the cells of the patients had reduced ATP production compared with cells from healthy controls. The lactone form of statins appears to reduce activity in a protein structure known as "complex III."
Prof. Russel says further independent studies are needed to look at the effects of different statins on mitochondrial function, and to confirm whether the mechanism they have identified could be a useful marker to predict which patients are likely to experience side effects from statin use. He also notes that:
"Interindividual differences in the enzymatic conversion of the acid into the lactone form could be an explanation for the differences between patients in susceptibility for statin-induced muscle pain."
He and his colleagues believe their findings will lead to new classes of cholesterol-lowering drugs without the unwanted muscle effects. 
In their study, the team also found they could reduce lactone's ability to interfere with mitochondrial function, suggesting there are ways to prevent or reverse the side effects of statins.
The team is currently pursuing both opportunities.
Meanwhile,  Medical News Today recently learned about new research that suggests  statins are being used by very elderly Americans "without any evidence from testing."
Writing in JAMA Internal Medicine, the researchers note that despite a lack of clear recommendation for statin use in the very elderly, over the last decade or so there has been a large increase in the use of the cholesterol-lowering drugs among the over-80s.
Copyright: Medical News Today
http://www.medicalnewstoday.com/articles/298911.php?tw

No comments:

Post a Comment