WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Thursday, March 3, 2016

Possible progress against Parkinson’s

March 3, 2016

By B. D. Colen, Harvard Staff Writer

Implanted stem cells reduced symptoms of disease during experiment, researchers say


Harvard Stem Cell Institute (HSCI) researchers at University-affiliated McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease.
Ole Isacson and colleagues reported that dopamine-producing neurons derived from the skin cells of primates survived for more than two years after implantation into one of the animals, and markedly reduced its Parkinson’s symptoms. The primate did not require immunosuppression, the scientists reported in the journal Cell Stem Cell.
Penelope J. Hallett, an assistant professor of psychiatry at Harvard Medical School (HMS) who works at McLean with Isacson, is the first author on the paper.
Such positive results were only seen in one animal because the experimental protocols evolved and were improved over time. Originally, the experiments were conducted using neurons derived from embryonic stem cells, which required using immunosuppressive drugs in the animals, and did not produce results that were as positive.
The current experiments used induced pluripotent stem cells, or iPS cells, which use a patient’s own skin cells to create the stem cells and then the neurons, so the patient — or in this case, the primate — does not recognize the new dopamine-producing neurons as foreign and reject them.
“It’s very difficult to get cell survival in primates,” said Isacson, who has been refining his experiments for more than 15 years. “This is a very high bar to clear.” Isacson is an HSCI principal faculty member, an HMS professor of neurology, and director of the Center for Neuroregeneration Research/ Neuroregeneration Laboratories at McLean.
Isacson said the conclusion of this experiment marks “the first time that an animal has recovered to the same activity level he had before.” He noted that the animal was “able to move as fast around its home cage” as an animal without Parkinson’s, and had normal agility, though individual motions were still slowed by the disease.
In this latest experiment, the neurons were implanted into only one side of the animals’ brains, and the improvements were seen on the opposite side, as would be expected.
Parkinson’s, which may affect as many as 1 million Americans, is caused by a depletion of dopamine-producing neurons in the brain. The disease causes a range of symptoms, from mild tremors to dementia and death, and can include slowed movements, muscle rigidity, tremors, changes in speech, loss of autonomic movement, and related issues. Current treatments include medications, electrical implants in the brain, and, in a limited number of cases, fetal neuron transplants.
Isacson stressed that there are a number of technical hurdles to be cleared before his team will be ready for its first clinical trial. He said he and Kevin Eggan, another HSCI principal faculty member working on neurological diseases, as well as other Harvard clinicians “will have to establish a protocol we believe will be safe and desirable from a clinical standpoint.”
“Conservatively, I’d say we’re three years” from requesting the go-ahead from the U.S. Food and Drug Administration for a Phase 1 clinical trial, Isacson said.
“Our next year will be dedicated to making cells” free of contaminants, creating a matrix on which to grow cells that “is free of any animal proteins,” and establishing a cell-freezing protocol, which will be necessary for transporting and storing the cells. Additionally, he said, the researchers need to perfect cell-sorting technology.
The current experiments were funded by HSCI and the Harvard Miller Consortium
http://news.harvard.edu/gazette/story/2015/03/possible-progress-against-parkinsons/

No comments:

Post a Comment