Our Parkinson's Place: ADAPTIVE DEEP BRAIN STIMULATION FOR PARKINSON'S DISEASE

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Monday, April 11, 2016

ADAPTIVE DEEP BRAIN STIMULATION FOR PARKINSON'S DISEASE

11th April 2016 - New research

Conventional Deep Brain Stimulation is set by a movement disorders specialist and left running continuously without change until the next clinic visit. However, this continuous high voltage stimulation may interfere with normal functioning. In contrast, Adaptive deep brain stimulation (aDBS) has the potential to greatly improve the treatment of Parkinson's disease by optimizing deep brain
stimulation in real time according to fluctuating disease and medication state.
An external portable aDBS system prototype was developed that was designed for clinical testing in people with Parkinson's Disease who had externalised DBS electrodes.

The aDBS system was validated by testing both its sensing and stimulation capabilities, and then by testing it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with Parkinson's Disease, evidence was provided that it can track L-dopa and DBS-induced LFP spectral power changes among different patient's clinical states.

Compared to conventional deep brain stimulation (DBS) for people with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters.

To watch video: http://www.jove.com/video/51403/controlling-parkinson-s-disease-with-adaptive-deep-brain-stimulation

Reference : Medical Engineering and Physics [2016] [Epub ahead of print] (M.Arlotti, L.Rossi, M.Rosa, S.Marceglia, A.Priori)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/27029510
http://www.viartis.net/parkinsons.disease/news/160411.pdf mail@viartis.net
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http://www.viartis.net/parkinsons.disease/news/160411.pdf