WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Tuesday, April 25, 2017

Parkinson's disease will be curable with cortisol

25-APR-2017

DGIST (DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY)

CAPTION

Hydrocortisone binds to glucocorticoid receptor which in turn leads to expression of CREB. CREB increases parkin expression via binding to CREB binding motifs of parkin promoter region. Hydrocortisone-stimulated parkin expression results in the downregulation of the toxic parkin substrate AIMP2, which is beneficial for dopaminergic neuronal survival.

DGIST's research team has found a candidate substance which can prevent and cure Parkinson's disease. By using this substance, the team also has identified the mechanism of dopaminergic neuronal death inhibition. 
Parkinson's disease is a representative neurological degenerative brain disease caused by the death of dopaminergic neurons in the middle cerebral blood. It is a disease with high incidence in the population over the age of 60 and the symptoms are body tremor and stiffness, slow motion, posture instability, etc.
It is known that mutation or low expression of parkin protein, a part of the system which hydrolyzes intracellular proteins, accelerates the accumulation of toxic proteins that must be removed in cells and induces dopaminergic neuronal cell death and Parkinson's disease, a degenerative brain disease. 
Currently, Parkinson's disease is classified as a rare incurable disease, one of the Korean government's four major target serious illnesses. However, there are no drugs that can prevent the death of dopaminergic neurons.
The senior researcher Yoon-Il Lee's research team and Professor Yunjong Lee's research team have continuously conducted studies on the development of candidate substances to cure Parkinson's disease and their mechanisms. The researchers performed a high-throughput screening method to identify drug candidates that promote dopaminergic neuronal cell activation by inducing the expression of the parkin protein, the cell protection gene which can inhibit the death of dopaminergic neurons.
As a result, it has been identified that cortisol* , known as a stress hormone, induces the expression of the parkin protein and prevents dopaminergic neuronal death by eliminating the accumulation of cell death factors through ubiquitin proteasome system. 
In addition, the team has demonstrated the mechanism by which cortisol induces the expression of the parkin protein and CREB transcriptional regulator through the hormone receptor regulates the expression of the parkin protein through the cell and animal model experiments. The study also has assured the possibility that cortisol can be used as a therapeutic agent for degenerative Parkinson's disease. 
The senior researcher Yoon-Il Lee stated "The significance of this study is that it has identified that the expression of parkin protein induced by a moderate level of stress hormone cortisol could be an important factor in maintaining the viability of dopaminergic neurons. We will continue to conduct follow-up studies such as clinical studies so that the Parkinson's disease will be curable in the future."
https://eurekalert.org/pub_releases/2017-04/dgi-pdw042517.php

No comments:

Post a Comment