Welcome to Our Parkinson's Place

I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible. I have Parkinson's
diseases as well and thought it would be nice to have a place where
updated news is in one place. That is why I began this blog.
I am not responsible for it's contents, I am just a copier of information searched on the computer. Please understand the copies are just that, copies and at times, I am unable to enlarge the wording or keep it uniformed as I wish. This is for you to read and to always keep an open mind.
Please discuss this with your doctor, should you have any questions, or concerns. Never do anything without talking to your doctor. I do not make any money from this website. I volunteer my time to help all of us to be informed. Please No advertisers, and No Information about Herbal treatments. Please no advertisements.
This is a free site for all.
Thank you.

Wednesday, June 28, 2017

How Frequent Diarrhea Can Put You At Risk Of an Incurable Brain Disease

June 28, 2017

Your immune response to the dreaded stomach bug can have a dark side

The short-term effects of a stomach bug suck: cramps, vomiting, diarrhea, and an inability to stray more than a few feet from the toilet. But the long-term effects might be way more serious, research from Georgetown University Medical Center suggests.

That’s because when you get an upper GI infection—like in your esophagus, stomach, or the first section of your intestine—your body produces a certain protein called alpha-synuclein to aid in your immune response to fight off the bug, the researchers write in the Journal of Innate Immunity.

After taking intestinal biopsies in children with upper GI distress and intestinal-transplant patients infected with diarrhea-causing norovirus, the researchers discovered they both showed higher expression of the alpha-synuclein protein. That’s the protein implicated in conditions like Parkinson’s, a neurodegenerative disorder that affects your movement. It can’t be cured, though its symptoms can be treated.

In most cases, the influx of alpa-synuclein is a good thing. When the protein is triggered in normal amounts following an stomach bug, it attracts your white blood cells to the affected area to fight it off, explains study author Michael Zasloff, M.D., Ph.D., in a release. The protein produced by one nerve cell can spread to others, allowing it to protect the nervous system as well as the GI tract.

The protein can also use nerves that connect the GI tract to the brainstem as transit, providing access to the brain.

But too much of the protein—say, through multiple or chronic gut infections—can become toxic. It overwhelms your body’s system responsible for clearing it out, damaging nerves and leading to inflammation. The buildup of this protein may lead to those neurodegenerative diseases
The link makes sense, the researchers say. Many patients with Parkinson’s report chronic constipation, which can result from nerve damage in the gut decades before the brain symptoms begin The clinical implications of these finding down the line are intriguing: For instance, a clinical trial testing a drug that reduces the formation of toxic alpha-synuclein clumps is currently underway.

No comments:

Post a Comment