Introducing Antibodies against Alpha-Synuclein
The aforementioned Prothena is partnering with Roche to test its antibody (PRX002/RO7046015) against alpha-synuclein in people diagnosed with PD within the past two years (among other criteria). The trial is taking place in Austria, France, Germany, Spain and the United States.
Learn more on MJFF's trial matching site Fox Trial Finder: https://foxtrialfinder.michaeljfox.org/trial/4926/.
Harnessing the Power of the Immune System to Protect Cells
AFFiRiS aims to harness the body's natural immune response to neutralize alpha-synuclein by using a vaccine of synthetic protein to elicit antibodies (similar to how the flu vaccine works). MJFF has supported AFFiRiS through a pre-clinical study and Phase I trial, and the company is currently planning a Phase II trial. MJFF funding also allowed AFFiRiS to show participants respond to "boost" vaccines, which re-raise antibody levels. This information is useful as this therapy may require multiple doses.
Preventing Toxic Protein Clumps
Neuropore is developing the NPT200-11 compound, which binds to alpha-synuclein and blocks its accumulation. Pharma company UCB has taken over leadership of the project and is planning a Phase Ib study to look for safety and tolerability in both control volunteers and people with Parkinson's. The Ib study will be conducted at a single site in Europe.