I Ask This Of You!

I have Parkinson's diseases and thought it would be nice to have a place where the contents of updated news is found in one place. That is why I began this blog.

I copy news articles pertaining to research, news and information for Parkinson's disease, Dementia, the Brain, Depression and Parkinson's with Dystonia. I also post about Fundraising for Parkinson's disease and events. I try to be up-to-date as possible.

I am not responsible for it's contents. I am just a copier of information searched on the computer. Please understand the copies are just that, copies and at times, I am unable to enlarge the wording or keep it uniformed as I wish.

This is for you to read and to always keep an open mind.

Please discuss this with your doctor, should you have any questions, or concerns.

Never do anything without talking to your doctor. I do not make any money from this website. I volunteer my time to help all of us to be informed. I will not accept any information about Herbal treatments curing Parkinson's, dementia and etc. It will go into Spam.

This is a free site for all with no advertisements.

Thank you for visiting!

Friday, August 18, 2017

Parkinson's disease: meta-analysis confirms efficacy of adjuvant entecapone

August 18, 2017

Illustration sample only

  • Adjuvant entacapone (Comtan) outperformed placebo at improving measures of Parkinson’s disease (PD) symptoms, albeit with adverse effects.
Why this matters
  • Long-term treatment with levodopa often leads to development of motor complications, including unpredictable “on-off” fluctuations.
Key results
  • Relative to placebo-treated peers, patients treated with adjuvant entacapone had greater on time (mean difference [MD], 0.79; P<.01) and less off time (MD, –0.98; P<.01), and required a lower levodopa dose (MD, –37.82; P<.01).
  • Entacapone also netted better Unified Parkinson’s Disease Rating Scale part II (activities of daily living) scores (MD, –1.22 points; P<.01) and part III (motor) scores (MD, –2.38 points; P<.01).
  • However, entacapone-treated patients were more likely to withdraw beacuse of adverse events (OR, 1.44; P<.01), and to experience nausea (OR, 2.23; P<.01), urine discoloration (OR, 14.99; P<.01), gastrointestinal symptoms (OR, 2.6; P<.01) and dyskinesia (OR, 2.00; P<.01).
Study design
  • Systematic review/meta-analysis of 14 randomized controlled trials of adding entacapone vs placebo to levodopa among 2804 patients.
  • Follow-up ranged from 40 d to 24 wk.
  • Main outcomes were measures of efficacy and safety.
  • Funding: None.
  • Most trials were small and short, and did not detail randomization strategy.
  • Only 5 trials reported Unified Parkinson’s Disease Rating Scale part I-III scores.


      Efficacy and Safety of Adjuvant Treatment with Entacapone in Advanced Parkinson's Disease with Motor Fluctuation: A Systematic Meta-Analysis.

      Li J1Lou Z2Liu X1Sun Y1Chen J1.


      To assess the efficacy and safety of adjuvant treatment with entacapone in the treatment of later Parkinson's disease (PD) patients with motor fluctuation.


      We conducted a systematic review of relevant studies from 8 databases to June 23, 2016.


      Fourteen studies were included in this review (n = 2,804). The results showed that compared with placebo, adjuvant therapy with entacapone significantly increased on time (p < 0.01) and reduced off time (p < 0.01), the required levodopa (LD) dose (p < 0.01) and improved Parkinson's Disease Rating Scale (UPDRS) scores (activities of daily living score: p < 0.01; motor score: p < 0.01; UPDRS I-III score: p > 0.05). However, the withdrawal (OR 1.44, 95% CI 1.10-1.89, p < 0.01) due to adverse events and adverse events rates including nausea (OR 2.23, 95% CI 1.56-3.20, p < 0.01), urine discoloration (OR 14.99, 95% CI 7.63-29.44, p < 0.01), gastrointestinal disorder (OR 2.6, 95% CI 1.89-3.57, p < 0.01) and dyskinesia (OR 2.00, 95% CI 1.56-2.58, p < 0.01) increased in patients with entacapone compared with those given a placebo .


      This meta-analysis suggests that the entacapone used as adjuvant therapy to LD is effective in the management of later PD with fluctuation. However, patients on entacapone had a higher frequency of adverse events than those on placebo but no occurrence of severe adverse reactions.


      Efficacy and safety; Entacapone; Meta-analysis; Motor fluctuation; Parkinson’s disease

      No comments:

      Post a Comment