24th September 2015 - New research
For the first time a selection of blood-borne autoantibody biomarkers with a higher
prevalence in early Parkinson's Disease were used to facilitate the diagnosis of early
Parkinson's Disease. Antibodies are proteins produced by a person's immune system that
allows their body to distinguish between "self" and "non-self" proteins. For more information
go to : http://labtestsonline.org.uk/understanding/analytes/autoantibodies/tab/glance/
The sera of people with early stage Parkinson's Disease were screened with human protein
microarrays containing 9486 potential antigen targets in order to identify autoantibodies that
are potentially useful as biomarkers for Parkinson's Disease.
Selected, blood-borne autoantibody biomarkers with a
higher prevalence in early Parkinson's Disease could
distinguish early Parkinson's Disease with an overall
accuracy of 88%, a sensitivity of 94% and a specificity of
85%. These biomarkers were also capable of
differentiating people with early Parkinson's Disease from
those with mild to moderate Parkinson's Disease with an
overall accuracy of 97%. The biomarkers could also
distinguish people with early Parkinson's Disease from
those with other neurological disorders.
The results demonstrate, for the first time, that selected autoantibodies may prove to be
useful as effective blood-based biomarkers for the diagnosis of early Parkinson's Disease.
Reference : Immunology Letters [2015] Sep 16 [Epub ahead of print] (C.A.DeMarshall, M. Han, E.P.Nagele, A.Sarkar, N.K.Acharya, G.Godsey, E.L.Goldwaser, M.Kosciuk, U. Thayasivam, B.Belinka, R.G.Nagele)
Complete abstract : http://www.ncbi.nlm.nih.gov/pubmed/26386375
http://www.viartis.net/parkinsons.disease/news/150924.pdf mail@viartis.net
©2015 Viartis
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