WELCOME TO OUR PARKINSON'S PLACE!

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

TRANSLATE

Monday, October 10, 2016

Cell protein offers new hope in fighting the effects of aging

October 10, 2016


Credit: Peter Griffin/public domain



A protein found within the powerhouse of a cell could be the key to holding back the march of time, research by scientists at The University of Nottingham has shown.

The discovery could offer a new target for drugs that may help to slow the debilitating effects of aging on our bodies.
And their research, published in the academic journal Aging, could have special significance for combatting age-related decline and halting the progression of  such as Alzheimer's and Parkinson's Disease.


Researchers centred on a family of proteins called carbonic anhydrase found within mitochondria — the cells’ ‘batteries’ which convert the oxygen we breathe into the energy (ATP) needed to power our body. NeuroscienceNews image is for illustrative purposes only. (http://neurosciencenews.com/aging-protein-genetics-5256/)

The work, led by Dr Lisa Chakrabarti and PhD student Amelia Pollard in the University's School of Veterinary Medicine and Science, has centred on a family of proteins called  found within mitochondria—the cells' 'batteries' which convert the oxygen we breathe into the energy (ATP) needed to power our body.
Dr Chakrabarti said: "What's really exciting about this development is that we have been able to surmise that the function of this protein is playing a role in the aging process within the cell.
"This gives us a very promising start in working out how we can best target this protein within the mitochondria to slow the effects of aging in the body while limiting other unwanted side effects on the body. It could potentially offer a significant new avenue in both tackling degenerative illnesses and the general effects of aging on the body."
Using a specialist process called 2D gel electrophoresis, the scientists separated out all the proteins found within the mitochondria of brain cells and muscle cells from normal young brains and normal middle-aged brains and compared the two samples.
They found that the carbonic anhydrase was found in greater quantity and was more active in the samples of the middle-aged brain. Significantly, this increase was also reflected in samples from young brains suffering from early degeneration, suggesting that the increase is detrimental.
To establish whether this was indeed detrimental and not evidence of the body's attempt to guard against this degeneration—known as a protective effect—the scientists studied the effect of carbonic anhydrase on nematode worms.
They found that feeding carbonic anhydrase to the tiny c elegans worms—measuring around just one millimetre in length—reduced their life span.
As we age, our body's tissues and functions begin to diminish. Aging has been associated with a loss of muscle mass which begins around the age of 50 and becomes more pronounced in our 60s, leading to a reduction in strength and greater frailty.
Aging in the brain can cause the onset of cognitive impairment affecting memory, reasoning and multitasking and can lead to dementia. Other neurodegenerative diseases such as Alzheimer's and Parkinson's Disease can cause the early onset of cognitive decline.
The scientists are continuing their work to identify chemical compounds that may be successful in targeting carbonic anhydrase and to study what effect these potential inhibitors have on worms which have had their lives shortened by the protein.
The Nottingham study could be the first step to the development of a new type of drug that targets carbonic anhydrase in just the 's mitochondria to protect against aging and degeneration.
http://medicalxpress.com/news/2016-10-cell-protein-effects-aging.html

No comments:

Post a Comment