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Monday, October 10, 2016

Rats Have Greater Episodic Memory Than Previously Thought

NEUROSCIENCE NEWS
Summary: According to a new study, rats can remember more than 30 events in context.


Source: Indiana University.

Rats were challenged to remember which scent they had not yet smelled in their current context. Neurosciencenews image is credited to Indiana University.


Research contributes to efforts improve animal models used in research on human memory disorders. 

Anyone who has ever spotted a familiar face at a party but been unable to place where or when they last met that person knows the difference between episodic memory and familiarity.

Familiarity is mere recognition. Episodic memory is the ability to recall a memory’s context — to remember where and when you saw that familiar face. It’s also the difference between sputtering your way through a reintroduction or smoothly referring back to details about the last time you talked to your acquaintance.

Although it’s easy to grasp the difference in these types of memory in ourselves, it’s not easy to know how animals see the world. Do their memories also take context into account?
A new study by Indiana University researchers that appears online today in the journal Current Biology suggests that rats exhibit much stronger episodic memory than previously thought. It is the first study to show that these animals can remember more than 30 events in context.

The lead author on the study is Danielle Panoz-Brown, a graduate student in the lab of Jonathon Crystal, a professor in the IU Department of Psychological and Brain Sciences, who is also an author on the paper.

“Most work shows that rats, and other animals, remember one, two or perhaps three events,” Crystal said. “This new work shows that rats remember many events — over 30 — and are likely able to remember many more using episodic memory.”

He added that the existence of episodic memory in lower animals has implications for research on human diseases that affect memory, including Alzheimer’s, Parkinson’s and Huntington’s diseases, since the majority of research on the brain — and the drugs used to treat memory diseases and dementia — start out based on insights into how the brain works in rats.

So, if a pharmaceutical company creates an Alzheimer’s drug to target memory based on research into one type of memory — the part of the brain responsible for finding missing objects, for example — but doesn’t also have data on the type of memory that helps individuals remember the important people, places and things in their life, it runs the risk of producing a product that helps a person remember where they put the car keys, but not how they met their spouse.
That risk is the impetus behind several other studies published by Crystal over the past several years. In January, Crystal’s lab reported evidence that animals also possess independent working memory systems by showing that rats could remember a longer list of items when asked to recall a combination of physical locations and smells versus when they used only a single category of information. And prior to that, they found that rats also possess “source memory,” which is the ability to recall where a new piece of information was acquired.
To conduct the new study, Panoz-Brown and Crystal developed a series of challenges in which rats were asked to recall up to 30 different scents — basil, strawberry and banana, among many others — to earn a treat. However, they only earned the reward when they chose the correct scent in a certain context — one of two circular “arenas” with different black-and-white patterns on the floor.
The rats were exposed to a series of many odors and then taught to associate “new” odors — ones to which they had not been previously exposed — with food. After learning this “rule,” they were put into one arena and exposed to an odor (for example, a strawberry). They were then put into a second arena and exposed to two odors (such as blueberry and strawberry). Finally, they were placed back into the first arena and presented with two odors. They correctly chose blueberry as the “new” odor, despite their previous exposure in the other context.
The results suggest the rats realized the second odor counted as “new” since they had not yet encountered it in the second context. Moreover, the rats performed similarly on several other challenges, including a test designed to challenge their ability to recall these “rules” over time and an attempt to confuse them through rapidly switching the contexts.

“Our findings suggest that the ability to represent numerous episodic memories is quite old in the evolutionary timescale,” Crystal said. “More broadly, our work supports the view that rats may be used to model fundamental aspects of human memory.”
Unfortunately, not many researchers study these more-complex areas of memory. One major reason is that it’s just easier to target the parts of the brain that remember location. Automated technology used by many labs makes it easier to simply track a rat as it runs through a maze — a test of location-based memory — as opposed to studying more-sophisticated forms of memory.
For that, Crystal’s lab relies on a large team of undergraduate students who can prepare more-complex tests and closely monitor the results. IU undergraduate researchers who worked on this study were Hannah E. Corbin, Stefan J. Dalecki, Meredith Gentry, Sydney Brotheridge and Christina M. Sluka, who are all also authors on the paper. Also an author is Jie-En Wu, a member of Crystal’s lab who was a high school student at the time of the research reported in the paper.
ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE
Funding: This research was supported by the National Institutes of Health’s National Institute on Aging and the National Institute of Mental Health.
Source: Kevin Fryling – Indiana University
Image Source: This NeuroscienceNews.com image is credited to Indiana University.
Original Research: Abstract for “Rats Remember Items in Context Using Episodic Memory” by Danielle Panoz-Brown, Hannah E. Corbin, Stefan J. Dalecki, Meredith Gentry, Sydney Brotheridge, Christina M. Sluka, Jie-En Wu, and Jonathon D. Crystalin 
Current Biology. Published online September 29 2016 doi:10.1016/j.cub.2016.08.023


Abstract

Rats Remember Items in Context Using Episodic Memory
Highlights
•Rats remember many unique events using episodic memory
•Rats remembered items and the contexts in which they occurred using episodic memory
•The ability to represent numerous episodic memories is evolutionarily quite old
•Rats may be used to model fundamental aspects of human memory


Summary
Vivid episodic memories in people have been characterized as the replay of unique events in sequential order. Animal models of episodic memory have successfully documented episodic memory of a single event (e.g.,). However, a fundamental feature of episodic memory in people is that it involves multiple events, and notably, episodic memory impairments in human diseases are not limited to a single event. Critically, it is not known whether animals remember many unique events using episodic memory. Here, we show that rats remember many unique events and the contexts in which the events occurred using episodic memory. We used an olfactory memory assessment in which new (but not old) odors were rewarded using 32 items. Rats were presented with 16 odors in one context and the same odors in a second context. To attain high accuracy, the rats needed to remember item in context because each odor was rewarded as a new item in each context. The demands on item-in-context memory were varied by assessing memory with 2, 3, 5, or 15 unpredictable transitions between contexts, and item-in-context memory survived a 45 min retention interval challenge. When the memory of item in context was put in conflict with non-episodic familiarity cues, rats relied on item in context using episodic memory. Our findings suggest that rats remember multiple unique events and the contexts in which these events occurred using episodic memory and support the view that rats may be used to model fundamental aspects of human cognition.


“Rats Remember Items in Context Using Episodic Memory” by Danielle Panoz-Brown, Hannah E. Corbin, Stefan J. Dalecki, Meredith Gentry, Sydney Brotheridge, Christina M. Sluka, Jie-En Wu, and Jonathon D. Crystalin Current Biology. Published online September 29 2016 doi:10.1016/j.cub.2016.08.023

http://neurosciencenews.com/episodic-memory-rats-5181/

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