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Friday, March 24, 2017

UNMC scientists achieve research milestone with Parkinson’s disease

March 23, 2017


LINCOLN, Neb. - In an early phase human clinical trial, researchers at the University of Nebraska Medical Center tested a drug that transforms the immune system for diagnostic and therapeutic gain in Parkinson’s disease (PD). 
The medicine was proven safe and generally well tolerated. Side effects were minimal, but included skin irritation, bone pain and an allergic reaction. Preliminary evidence of improvement in motor skills was observed and recorded in several of the treated patients, but validation will require larger patient enrollments. 
PD ravages nearly one million Americans and generates direct and indirect costs of nearly $25 billion per year in the U.S. alone.
The findings – which appear today in the journal npj Parkinson's Disease – mark a milestone for PD research. At the heart of the discovery was the immune transformation of disease-inciting circulating white blood cells (called effector T-cells or Teff) to cells that protect and defend against brain injury (called regulatory T cells or Treg). The drug changed neurodestructive Teff into functional neuroprotective Tregs.

The three key people on the Phase I clinical trial were (left-right) Howard Gendelman, M.D., Pamela Santamaria, M.D., and R. Lee Mosley, Ph.D. (Photo courtesy UNMC)

The research team was headed by two UNMC scientists, Howard Gendelman, M.D., professor and chair of the Department of Pharmacology and Experimental Neuroscience, and R. Lee Mosley, Ph.D., professor of Pharmacology and Experimental Neuroscience and head of the Movement Disorders Research Laboratory. The discovery results from more than two decades of laboratory and animal investigation.
The idea was conceived in cell studies then validated in animals. During each step, immune transformation was realized with the drug granulocyte macrophage colony stimulating factor (also known as Sargramostim® Sanofi-Genzyme Pharmaceuticals).
Importantly, such drug-induced transformation has not only been successful for PD but also holds promise for a range of neurodegenerative disorders that include Alzheimer’s disease, stroke and amyotrophic lateral sclerosis.
To conduct the Phase I clinical study, scientists partnered with 14 academic and community-based physicians and neuroscientists with extensive expertise in neurophysiology, bioimaging, clinical trials execution and movement disorders. The research was conducted in basic science laboratories at UNMC and Scripps Research Institute in La Jolla, Calif. The study subjects were seen at UNMC’s clinical partner, Nebraska Medicine.
Clinical support was overseen at UNMC by Pamela Santamaria, M.D., a Nebraska Medicine neurologist and founder of Neurology Consultants of Nebraska; Danish Bhatti, M.D., assistant professor in the Department of Neurological Sciences; and by David Standaert, M.D., Ph.D., professor and chair of Neurology and director of the Division of Movement Disorders at the University of Alabama at Birmingham. 
Using a blinded clinical study approach for investigation, the patients, their caregivers and their physicians could not tell whether the drug or a placebo was being administered.
The drug was found to produce significant and encouraging changes in the production of Treg cells in the blood of patients. These same changes did not take place in patients who received the placebo. Initial clinical observations proved encouraging and varied in intensity between patients, Dr. Gendelman said. 
During the trial, physiological brain improvements were seen in specific motor areas of the brain for those patients receiving Sargramostim. This was recorded through the use of magnetoencephalography by a research team headed by Tony Wilson, Ph.D., associate professor and vice chair, basic/translational research for UNMC and director of the Magnetoencephalography Laboratory in the Department of Neurological Sciences.
Blood metabolites known to increase the number of neuroprotective Treg cells were observed in parallel studies on the same blood samples used to record the immune biomarkers. These biochemical studies were performed at the Scripps Research Institute by Gary Siuzdak, Ph.D., professor and director, Scripps Center for Metabolomics and Mass Spectrometry. 
Doses of L-DOPA and other dopamine-sparing drugs used to treat PD were continued to all study subjects throughout the study.
“To our knowledge, this study represents the first time immune transformation was performed on any patient with neurodegenerative disease,” Dr. Mosley said.
Dr. Gendelman said the next step will be a broader study that will include larger patient numbers. This is being planned in the next one to two years, he said, after the manufacture of an oral medicine. 
For more information on the study, call 402-559-6941.
http://www.1011now.com/content/news/UNMC-scientists-achieve-research-milestone-with-Parkinsons-disease--416935353.html

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