Our Parkinson's Place: Mitsubishi Tanabe bags NeuroDerm and its PhIII Parkinson’s program for $1.1B

I HAVE PARKINSON'S DISEASES AND THOUGHT IT WOULD BE NICE TO HAVE A PLACE WHERE THE CONTENTS OF UPDATED NEWS IS FOUND IN ONE PLACE. THAT IS WHY I BEGAN THIS BLOG.

I COPY NEWS ARTICLES PERTAINING TO RESEARCH, NEWS AND INFORMATION FOR PARKINSON'S DISEASE, DEMENTIA, THE BRAIN, DEPRESSION AND PARKINSON'S WITH DYSTONIA. I ALSO POST ABOUT FUNDRAISING FOR PARKINSON'S DISEASE AND EVENTS. I TRY TO BE UP-TO-DATE AS POSSIBLE.

I AM NOT RESPONSIBLE FOR IT'S CONTENTS. I AM JUST A COPIER OF INFORMATION SEARCHED ON THE COMPUTER. PLEASE UNDERSTAND THE COPIES ARE JUST THAT, COPIES AND AT TIMES, I AM UNABLE TO ENLARGE THE WORDING OR KEEP IT UNIFORMED AS I WISH. IT IS IMPORTANT TO UNDERSTAND I AM A PERSON WITH PARKINSON'S DISEASE. I HAVE NO MEDICAL EDUCATION,

I JUST WANT TO SHARE WITH YOU WHAT I READ ON THE INTERNET. IT IS UP TO YOU TO DECIDE WHETHER TO READ IT AND TALK IT OVER WITH YOUR DOCTOR. I AM JUST THE COPIER OF DOCUMENTS FROM THE COMPUTER. I DO NOT HAVE PROOF OF FACT OR FICTION OF THE ARTICLE. I ALSO TRY TO PLACE A LINK AT THE BOTTOM OF EACH ARTICLE TO SHOW WHERE I RECEIVED THE INFORMATION SO THAT YOU MAY WANT TO VISIT THEIR SITE.

THIS IS FOR YOU TO READ AND TO ALWAYS KEEP AN OPEN MIND.

PLEASE DISCUSS THIS WITH YOUR DOCTOR, SHOULD YOU HAVE ANY QUESTIONS, OR CONCERNS. NEVER DO ANYTHING WITHOUT TALKING TO YOUR DOCTOR FIRST..

I DO NOT MAKE ANY MONEY FROM THIS WEBSITE. I VOLUNTEER MY TIME TO HELP ALL OF US TO BE INFORMED.

I WILL NOT ACCEPT ANY ADVERTISEMENT OR HEALING POWERS, HEALING FROM HERBS AND ETC. UNLESS IT HAS GONE THROUGH TRIALS AND APPROVED BY FDA. IT WILL GO INTO SPAM.

THIS IS A FREE SITE FOR ALL WITH NO ADVERTISEMENTS

THANK YOU FOR VISITING! TOGETHER WE CAN MAKE A DIFFERENCE!

Monday, July 24, 2017

Mitsubishi Tanabe bags NeuroDerm and its PhIII Parkinson’s program for $1.1B

July 24, 2017 By John Caroll

Masayuki Mitsuka —President Mitsubishi Tanabe

Mitsubishi Tanabe is gobbling up the Israeli biotech NeuroDerm $NDRM, offering an early morning taste of the M&A activity that has been woefully short in the industry so far this year.

The Japanese pharma company agreed to pay $1.1 billion for the biotech, which has been developing a lead program for continued dosing of levodopa/carbidopa for Parkinson’s patients. That’s $39 a share, or a 79% premium over the unaffected early June price.

NeuroDerm’s biggest accomplishment has been developing a liquid formulation of levodopa/carbidopa that could be continuously delivered via a wearable pump. The Japanese buyer thinks this will fit well with Radicava, its newly approved ALS drug that is being launched next month in the US. NeuroDerm is also developing apomorphine, a mid-stage program for Parkinson’s, and a transdermal patch for CNS diseases and cognitive disorders.

Peter Wellford at Jefferies has been a keen advocate of the company’s prospects, projecting peak sales of its late-stage ND0612 at $1.7 billion – provided it gained an approval.

Wellford noted today:

Both ‘0612L/H are liquid formulations of the current Parkinson’s disease (PD) standard-of-care L-dopa/carbidopa as NeuroDerm has circumvented challenging chemistry to overcome the short half-life and poor bioavailability that has plagued L-dopa oral use. A convenient, continuous infusion of L-dopa could offer substantial clinical benefits for more advanced PD patients, avoiding the fluctuations of peak-dose dyskinesias and wearing-off, plus the potential for improved quality of sleep and delayed morning “on” given night-time dosing. We forecast $1.7bn WW peak sales, including $900m in the US. Assuming 50% probability of success, arguably overly cautious given the products’ profile, and late-2019E launches we derive a $37/share NPV.

Just a few weeks ago investigators outlined data indicating that the new dosing approach was effective in reducing “off” times for patients.

Most analysts started the year looking for a boost in the level of M&A deals in biopharma this year. But aside from the Ariad and Actelion buyouts along with a short string of smaller deals like this, the big buyers have not been eager to pay large premiums for new experimental products.

https://endpts.com/mitsubishi-tanabe-bags-neuroderm-and-its-phiii-parkinsons-program-for-1-1b/